Inhibition of Wnt signaling by ICAT, a novel β-catenin-interacting protein
Inhibition of Wnt signaling by ICAT, a novel β-catenin-interacting protein
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DOI：
10.1101/gad.14.14.1741
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发表时间：
2000-07
影响因子：
10.5
通讯作者：
K. Tago;Tsutomu Nakamura;M. Nishita;J. Hyodo;S. Nagai;Y. Murata;S. Adachi;S. Ohwada;Y. Morishita-Y
中科院分区：
文献类型：
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作者：
K. Tago;Tsutomu Nakamura;M. Nishita;J. Hyodo;S. Nagai;Y. Murata;S. Adachi;S. Ohwada;Y. Morishita-Y
Wnt信号传导在胚胎发育和肿瘤发生中具有重要作用。 β-Catenin 是 Wnt 信号通路的关键组成部分，与转录因子 TCF/LEF 家族相互作用并激活 Wnt 靶基因的转录。在这里，我们鉴定了一种新型 β-连环蛋白相互作用蛋白 ICAT，它被发现可以抑制 β-连环蛋白与 TCF-4 的相互作用，并抑制 β-连环蛋白-TCF-4 介导的反式激活。此外，ICAT 通过干扰 Wnt 信号传导来抑制非洲爪蟾轴的形成。这些结果表明，ICAT 通过抑制 β-连环蛋白和 TCF 之间的相互作用来负向调节 Wnt 信号传导，并且是发育和细胞增殖中不可或缺的一部分。
Wnt signaling has an important role in both embryonic development and tumorigenesis. β-Catenin, a key component of the Wnt signaling pathway, interacts with the TCF/LEF family of transcription factors and activates transcription of Wnt target genes. Here, we identify a novel β-catenin-interacting protein, ICAT, that was found to inhibit the interaction of β-catenin with TCF-4 and represses β-catenin–TCF-4-mediated transactivation. Furthermore, ICAT inhibited Xenopus axis formation by interfering with Wnt signaling. These results suggest that ICAT negatively regulates Wnt signaling via inhibition of the interaction between β-catenin and TCF and is integral in development and cell proliferation.