Vehicle exhaust outside the home and onset of asthma among adults
Vehicle exhaust outside the home and onset of asthma among adults
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DOI：
10.1183/09031936.00101108
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发表时间：
2009-06-01
影响因子：
24.3
通讯作者：
Forsberg, B.
中科院分区：
文献类型：
--
作者：
Modig, L.;Toren, K.;Forsberg, B.
很少有研究调查汽车尾气与成人新发哮喘之间的关系。本前瞻性队列研究的目的是调查成人哮喘累积发病率和哮喘发作与家中汽车尾气浓度之间的关系。来自北欧呼吸健康队列的三个瑞典城市的参与者构成了研究人群。使用离散模型计算每个参与者家中的暴露量。我们还使用距离最近的主要道路< 50米的距离作为更简单的暴露指标。调整后的模型包括3609名参与者，其中107人被归类为哮喘发病病例，55人被归类为哮喘真实发病病例。哮喘发作(比值比（OR）每10亩g·m（-3) 1.46, 95%可信区间（CI） 1.07-1.99）与哮喘发生率（OR / 10亩g·m(-3) 1.54, 95% CI 1.00-2.36）与二氧化氮（NO2）水平呈正相关，在校正潜在混杂因素后仍具有统计学意义。哮喘与二氧化氮的关系不受性别、花粉热或喘息的影响。患哮喘的风险与居住在主干道附近也有显著关系。目前的研究表明，室外车辆废气水平升高会增加成年人患哮喘的风险。
Few studies have investigated the relationship between vehicle exhaust and the new onset of asthma among adults. The aim of the present prospective cohort study was to investigate the relationship between the cumulative incidence of asthma and onset of asthma among adults and vehicle exhaust concentrations at home.Participants from three Swedish cities included in the Respiratory Health in Northern Europe cohort constituted the study population. Exposure at each participant's home was calculated using dispersion models. We also used < 50 m distance to nearest major road as a more simple indicator of exposure. The adjusted model included 3,609 participants, of which 107 were classified as onset cases and 55 as true incident cases of asthma.There was a positive association between asthma onset (odds ratio (OR) per 10 mu g.m(-3) 1.46, 95% confidence interval (CI) 1.07-1.99) and incident asthma (OR per 10 mu g.m(-3) 1.54, 95% CI 1.00-2.36) and the levels of nitrogen dioxide (NO2), which remained statistically significant after adjusting for potential confounders. The relationship between asthma and NO2 was not significantly modified by sex, hay fever or wheeze. The risk of developing asthma was also significantly related to living close to a major road.The current study suggests that elevated levels of vehicle exhaust outside the home increase the risk of onset and incident asthma among adults.