Development of a novel method for visualizing restricted diffusion using subtraction of apparent diffusion coefficient values
Development of a novel method for visualizing restricted diffusion using subtraction of apparent diffusion coefficient values
复制标题
DOI：
10.3892/mmr.2019.10523
复制
发表时间：
2019-09-01
影响因子：
3.4
通讯作者：
Asaumi, Junichi
中科院分区：
文献类型：
--
作者：
Yoshimura, Yuuki;Kuroda, Masahiro;Asaumi, Junichi
为了显示受限扩散，本研究开发了一种新的方法称为“表观扩散系数（ADC）减法（ASM）”，并将其与扩散峰度成像（DKI）进行了比较。用两种不同有效扩散时间的序列分别获得生理盐水、低细胞密度和最高细胞密度生物体的扩散加权像。然后，减去计算的ADC值。生理盐水、低细胞密度和最高细胞密度模型的ADC值的平均值和标准差（SD）分别为2.95 +/- 0.08x10（-3）、1.90 +/- 0.35x10（-3）和0.79 +/- 0.05x10（-3）mm（2）/sec。DKI的平均峰度值和SD分别为0.04 +/- 0.01、0.44 +/- 0.13和1.27 +/- 0.03。ASM和SD值分别为0.25 +/- 0.20x10（4）、0.51 +/- 0.41x10（4）和4.80 +/- 4.51x10（4）（sec/mm（2））（2）。使用生物模型，本研究表明DKI在细胞外空间中表现出受限的扩散。类似地，ASM可以反映细胞外间隙中受限扩散的程度。
In order to visualize restricted diffusion, the present study developed a novel method called 'apparent diffusion coefficient (ADC) subtraction method (ASM)' and compared it with diffusion kurtosis imaging (DKI). The diffusion-weighted images of physiological saline, in addtion to bio-phatoms of low cell density and the highest cell density were obtained using two sequences with different effective diffusion times. Then, the calculated ADC values were subtracted. The mean values and standard deviations (SD) of the ADC values of physiological saline, low cell density and the highest cell density phantoms were 2.95 +/- 0.08x10(-3), 1.90 +/- 0.35x10(-3) and 0.79 +/- 0.05x10(-3) mm(2)/sec, respectively. The mean kurtosis values and SD of DKI were 0.04 +/- 0.01, 0.44 +/- 0.13 and 1.27 +/- 0.03, respectively. The ASM and SD values were 0.25 +/- 0.20x10(4), 0.51 +/- 0.41x10(4) and 4.80 +/- 4.51x10(4) (sec/mm(2))(2), respectively. Using bio-phantoms, the present study demonstrated that DKI exhibits restricted diffusion in the extracellular space. Similarly, ASM may reflect the extent of restricted diffusion in the extracellular space.