Gastric retention properties of superporous hydrogel composites
Gastric retention properties of superporous hydrogel composites
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DOI：
10.1016/s0168-3659(99)00139-x
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发表时间：
2000-02-14
影响因子：
10.8
通讯作者：
Park, K
中科院分区：
文献类型：
--
作者：
Chen, J;Blevins, WE;Park, K
在许多应用中，传统水凝胶的用途受到其缓慢膨胀的限制。为了改善常规水凝胶的膨胀性能，我们合成了超多孔水凝胶（SPHs），由于毛细管润湿通过许多相互连接的开孔吸水，SPHs在几分钟内迅速膨胀到平衡尺寸。膨胀率也很大，在数百的范围内。在合成过程中加入复合材料可提高高膨胀SPHs的机械强度。用于合成SPH复合材料的复合材料为Ac-Di-Sol(R)（交联棉糖钠）。制备的SPH复合材料在禁食和喂养条件下对狗的胃潴留特性进行了测试。SPH复合材料放置在硬明胶胶囊（大小为000）中口服。所有实验犬在实验前禁食36小时。在禁食条件下，SPH复合物在胃中停留2-3 h后分解成两半并排空。在禁食36小时后，实验前只给一次食物，SPH复合物在胃中停留超过24小时，即使喂食条件只维持了最初的几个小时。我们的研究表明，SPH复合材料具有胃潴留所必需的三个特性：快速肿胀；superswelling;且机械强度高。虽然还需要进一步改进，但SPH复合材料为开发有效的长期胃潴留装置提供了基础。(C) 2000 Elsevier Science B.V.版权所有
In many applications, usefulness of conventional hydrogels is limited by their slow swelling. To improve the swelling property of the conventional hydrogels, we have synthesized superporous hydrogels (SPHs) which swell fast to equilibrium size in minutes due to water uptake by capillary wetting through numerous interconnected open pores. The swelling ratio was also large in the range of hundreds. The mechanical strength of the highly swollen SPHs was increased by adding a composite material during the synthesis. The composite material used in the synthesis of SPH composites was Ac-Di-Sol(R) (croscarmellose sodium). The gastric retention property of the prepared SPH composites was tested in dogs both in fasted and fed conditions. The SPH composites were placed in a hard gelatin capsule (size 000) for oral administration. All dogs tested were fasted for 36 h before experiments. Under the fasted condition, the SPH composite remained in the stomach for 2-3 h after before breaking into two pieces and being emptied. When food was given before the experiment just once following 36 h of fasting, the SPH composite remained in the stomach for more than 24 h, even though the fed condition was maintained only for the first few hours. Our study indicated that SPH composites possessed three properties necessary for gastric retention: fast swelling; superswelling; and high mechanical strength. While more improvements need to be made, the SPH composites provide the basis for the development of effective long-term gastric retention devices. (C) 2000 Elsevier Science B.V. All rights reserved.