Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome
Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome
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DOI：
10.1080/09513590801893232
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发表时间：
2008-01-01
影响因子：
2
通讯作者：
Jasonni, Valerio M.
中科院分区：
文献类型：
--
作者：
Genazzani, Alessandro D.;Lanzoni, Chiara;Jasonni, Valerio M.
Objective.评价肌醇（MYO）对多囊卵巢综合征（PCOS）患者激素水平的影响。对照临床研究。设置。临床研究环境中的PCOS患者。20例超重PCOS患者在知情同意后入组。所有患者在治疗前和治疗12周后进行激素评估和口服葡萄糖耐受试验（OGTT）（A组（n=10）：肌醇2 gr。B组（n=10）：叶酸200 g/d。同时进行超声检查和Ferriman-Gallwey评分。血浆LH、FSH、PRL、E2、17 OHP、A、T、血糖、胰岛素、C肽浓度、BMI、HOMA指数和葡萄糖/胰岛素比值。MYO给药12周后，血浆LH、PRL、T、胰岛素水平和LH/FSH均显著降低。治疗12周后，胰岛素敏感性（以葡萄糖胰岛素比和HOMA指数表示）显著改善。月经周期性恢复在所有闭经和月经过少受试者。叶酸治疗组无明显变化。肌醇治疗改善PCOS患者生殖轴功能，降低影响LH分泌的高胰岛素血症状态。
Objective. To evaluate the effects the administration of myo-inositol (MYO) on hormonal parameters in a group of PCOS patients.Design. Controlled clinical study.Setting. PCOS patients in a clinical research environment.Patients. 20 overweight PCOS patients were enrolled after informed consent.Interventions. All patients underwent hormonal evaluations and an oral glucose tollerance test (OGTT) before and after 12 weeks of therapy (Group A (n=10): myo-inositol 2gr. plus folic acid 200g every day; Group B (n=10): folic acid 200g every day). Ultrasound examinations and Ferriman-Gallwey score were also performed.Main outcome measures. Plasma LH, FSH, PRL, E2, 17OHP, A, T, glucose, insulin, C peptide concentrations, BMI, HOMA index and glucose-to-insulin ratio.Results. After 12 weeks of MYO administration plasma LH, PRL, T, insulin levels and LH/FSH resulted significantly reduced. Insulin sensitivity, expressed as glucose-to-insulin ratio and HOMA index resulted significantly improved after 12 weeks of treatment. Menstrual cyclicity was restored in all amenorrheic and oligomenorrheic subjects. No changes occurred in the patients treated with folic acid.Conclusions. Myo-inositol administration improves reproductive axis functioning in PCOS patients reducing the hyperinsulinemic state that affects LH secretion.