Development and Application of Crown Ether-based HPLC Chiral Stationary Phases
Development and Application of Crown Ether-based HPLC Chiral Stationary Phases
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冠醚HPLC手性固定相的开发及应用
DOI：
10.5012/bkcs.2005.26.8.1153
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发表时间：
2005
影响因子：
1.7
通讯作者：
M. Hyun
中科院分区：
文献类型：
--
作者：
M. Hyun
基于冠醚的 HPLC 手性固定相 (CSP) 已成功用于拆分各种含有伯氨基的外消旋化合物。特别是，基于掺有手性联萘单元或酒石酸单元的手性冠醚和基于酚类假手性冠醚的CSP表现出高手性识别效率。本文综述了冠醚型高效液相色谱CSP的发展、其结构特征以及在拆分外消旋化合物（包括含有伯氨基或仲氨基的手性药物）时随流动相组分类型和含量以及柱温变化的应用。
Crown ether-based HPLC chiral stationary phases (CSPs) have been successfully utilized in the resolution of various racemic compounds containing a primary amino group. Especially, CSPs based on chiral crown ethers incorporating chiral binaphthyl unit or tartaric acid unit and based on phenolic pseudo chiral crown ethers have shown high chiral recognition efficiency. In this account paper, a review on the development of crown etherbased HPLC CSPs, their structural characteristics and applications to the resolution of racemic compounds including chiral drugs containing a primary or secondary amino group with the variation of the type and the content of mobile phase components and with the variation of the column temperature is presented.