Global burden of oesophageal and gastric cancer by histology and subsite in 2018
Global burden of oesophageal and gastric cancer by histology and subsite in 2018
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DOI：
10.1136/gutjnl-2020-321600
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发表时间：
2020-09-01
期刊：
影响因子：
24.5
通讯作者：
Soerjomataram, Isabelle
中科院分区：
文献类型：
--
作者：
Arnold, Melina;Ferlay, Jacques;Soerjomataram, Isabelle
目的按亚位点和类型提供全球食管癌和胃癌负担的最新估计。方法使用基于人群的癌症登记处的数据，按国家、性别和年龄组计算食管癌（OAC）和鳞状细胞癌（OSCC）占所有食管癌、贲门癌（CGC）和非CGC （NCGC）占所有胃癌病例的比例。随后将比例应用于GLOBOCAN 2018中食管癌和胃癌病例的估计数量。计算年龄标准化发病率（ASR）。结果2018年，全球估计有57.2万例食管癌新发病例，其中8.5万例OAC（每10万人中有0.9例ASR，男女合并）和48.2万例oscc （ASR为5.3）。在103万例胃癌中，估计有18.1万例CGC （ASR 2.0）和85.3万例NCGC （ASR 9.2）。东亚地区OSCC、CGC和NCGC的发病率最高（ASR分别为11.1、4.4和17.9），而北欧地区OAC的发病率最高（ASR为3.5）。虽然在全球范围内，OSCC和NCGC仍然是最常见的食管癌和胃癌类型，但在越来越多的高收入国家，OAC的发病率超过了OSCC。这些根据亚型和部位对全球食管癌和胃癌负担的最新估计表明，流行病学模式正在发生转变。这项工作将作为决策的基石，并将有助于制定适当的癌症控制战略。
Objectives To provide updated estimates of the global burden of oesophageal and gastric cancer by subsite and type.Methods Using data from population-based cancer registries, proportions of oesophageal adenocarcinoma (OAC) and squamous cell carcinoma (OSCC) out of all oesophageal as well as cardia gastric cancer (CGC) and non-CGC (NCGC) out of all gastric cancer cases were computed by country, sex and age group. Proportions were subsequently applied to the estimated numbers of oesophageal and gastric cancer cases from GLOBOCAN 2018. Age-standardised incidence rates (ASR) were calculated.Results In 2018, there were an estimated 572 000 new cases of oesophageal cancer worldwide, 85 000 OAC s (ASR 0.9 per 100 000, both sexes combined) and 482 000 OSCCs (ASR 5.3). Out of 1.03 million gastric cancers, there were an estimated 181 000 cases of CGC (ASR 2.0) and 853 000 cases of NCGC (ASR 9.2). While the highest incidence rates of OSCC, CGC and NCGC were observed in Eastern Asia (ASRs 11.1, 4.4 and 17.9, respectively), rates of OAC were highest in Northern Europe (ASR 3.5). While globally OSCC and NCGC remain the most common types of oesophageal and gastric cancer, respectively, rates of OAC exceed those of OSCC in an increasing number of high-income countries.Conclusions These updated estimates of the global burden of oesophageal and gastric cancer by subtype and site suggest an ongoing transition in epidemiological patterns. This work will serve as a cornerstone for policy-making and will aid in developing appropriate cancer control strategies.