Hemoglobin-Based Nanoarchitectonic Assemblies as Oxygen Carriers
Hemoglobin-Based Nanoarchitectonic Assemblies as Oxygen Carriers
复制标题
作为氧载体的基于血红蛋白的纳米结构组件
DOI：
10.1002/adma.201502581
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发表时间：
2016-02-10
影响因子：
29.4
通讯作者：
Li, Junbai
中科院分区：
文献类型：
--
作者：
Jia, Yi;Duan, Li;Li, Junbai
由于传统输血存在的问题和临床上的巨大需求，安全、有效的人工氧载体成为研究的热点。血红蛋白具有独特的氧运输能力和正常的代谢途径，被认为是理想的携氧单位。随着纳米生物技术的发展，血红蛋白组装体作为人工氧载体得到了很大的发展。本文从非细胞血红蛋白氧载体和细胞血红蛋白氧载体两个方面介绍了血红蛋白氧载体的研究进展。这些新型载氧体具有传统载氧体无法比拟的优点，将极大地推动可靠、可行的载氧体的研究。
Safe and effective artificial oxygen carriers are the subject of great interest due to the problems of traditional blood transfusion and enormous demand in clinical use. In view of its unique oxygen-transport ability and normal metabolic pathways, hemoglobin is regarded as an ideal oxygen-carrying unit. With advances in nano-biotechnology, hemoglobin assemblies as artificial oxygen carriers achieve great development. Here, recent progress on hemoglobin-based oxygen carriers is highlighted in view of two aspects: acellular hemoglobin-based oxygen carriers and cellular hemoglobin-based oxygen carriers. These novel oxygen carriers exhibit advantages over traditional carriers and will greatly promote research on reliable and feasible oxygen carriers.