Keloids and neoplasms in the Rubinstein-Taybi syndrome.
Keloids and neoplasms in the Rubinstein-Taybi syndrome.
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Rubinstein-Taybi 综合征中的瘢痕疙瘩和肿瘤。
DOI：
10.1002/mpo.2950170526
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Miller,RW
中科院分区：
文献类型：
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作者：
Siraganian,PA;Rubinstein,JH;Miller,RW
在574例Rubinstein‐Taybi综合征患者中，28例患有瘢痕疙瘩，19例患有一种或多种肿瘤。恶性肿瘤的排列并不表明有共同的病因或发病机制。一个可能的例外是观察到4例白血病。当恶性和良性肿瘤的数据结合起来时，22个中至少有9个可能是由发育错误引起的。瘢痕疙瘩形成明显过量表明对轻度损伤的过度反应，与肿瘤形成无关，但在未来的瘢痕形成研究中具有潜在的意义。
In a series of 574 individuals with the Rubinstein‐Taybi syndrome, 28 had keloids, and 19 had one or more neoplasms. The array of malignant neoplasms does not suggest an etiology or pathogenesis in common. One possible exception is that four cases of leukemia were observed. When the data for malignant and benign neoplasms were combined, at least nine of the 22 could have arisen from developmental errors. The apparent excess of keloid formation indicates overreaction to mild injury, with no known relevance to neoplasia but of potential interest in future studies of scar formation.