Percutaneous absorption of gold sodium thiosulfate used for patch testing
Percutaneous absorption of gold sodium thiosulfate used for patch testing
复制标题
硫代硫酸金钠经皮吸收斑贴试验
DOI：
10.1111/j.0105-1873.2004.00398.x
复制
发表时间：
2004
影响因子：
5.5
通讯作者：
M. Bruze
中科院分区：
文献类型：
--
作者：
H. Möller;A. Schütz;B. Björkner;M. Bruze
对黄金的接触性过敏已被证明与佩戴黄金首饰以及牙科金的存在有关。金致敏和引发过敏性接触性皮炎的先决条件是过敏原的电离和经皮吸收。本研究的目的是在用硫代硫酸金钠 (GSTS) 进行闭塞斑贴试验后证明血液中含有金。患者使用 GSTS 0.5、2.0 和 5.0% 凡士林溶液进行斑贴测试。在测试前以及第 3 天 (D3) 或第 7 天 (D7) 采集静脉血样本。通过电感耦合等离子体质谱法分析血金水平。在所有 66 名患者中，第二份血液样本中的金含量显着高于第 1 份（中位数为 0.34 µg/l 与 0.03 µg/l）。对金过敏和不过敏的患者的增加相似。经皮施用后，第 3 天和第 7 天的金水平没有差异。据推测，在斑贴测试期间，其他过敏原也可能被吸收到血液中。
Contact allergy to gold has been shown to be correlated to wearing of golden jewellery as well as to the presence of dental gold. The prerequisite for sensitization and elicitation of an allergic contact dermatitis to gold is ionization and percutaneous absorption of the allergen. The present study was undertaken with the aim to demonstrate gold in blood after an occlusive patch testing with gold sodium thiosulfate (GSTS). Patients were patch tested with GSTS 0.5, 2.0 and 5.0% in petrolatum. Venous blood was sampled before testing as well as on day 3 (D3) or day 7 (D7). Blood gold levels were analysed by inductively coupled plasma mass spectrometry. In all 66 patients, the blood level of gold was significantly higher in the 2nd blood sample than in the 1st (median 0.34 versus 0.03 µg/l). The increase was similar in patients allergic and not allergic to gold. There was no difference between gold levels on D3 and on D7 after epicutaneous application. Presumably, other allergens may also be taken up in blood during patch testing.