Transmission of SARS-CoV-2 variant B.1.1.7 among vaccinated health care workers
Transmission of SARS-CoV-2 variant B.1.1.7 among vaccinated health care workers
复制标题
DOI：
10.1080/23744235.2021.1945139
复制
发表时间：
2021-06-26
影响因子：
5.8
通讯作者：
Kofteridis, Diamantis P.
中科院分区：
文献类型：
--
作者：
Ioannou, Petros;Karakonstantis, Stamatis;Kofteridis, Diamantis P.
背景接种COVID-19疫苗是阻止疾病传播的最有效措施之一。然而，HCW对COVID-19疫苗接种的接受程度并不普遍，并且出现了新的变体，其传播性增加，BNT 162 b2疫苗引起的血清中和作用降低，并且能够在接种疫苗的个体中引起突破性感染，这令人担忧。本研究的目的是比较接种疫苗（BNT 162 b2）和未接种疫苗的医护人员（HCW）的病毒载量、诊断时的临床表现和暴露类型。方法对1月4日至4月14日通过鼻咽PCR诊断为COVID-19的HWC进行前瞻性队列研究。病毒载量用PCR中的循环阈值（Ct）表示。结果在研究期间，发现55名医护人员SARS-CoV-2阳性，其中大多数（44/55）是在3月28日至4月14日期间在医院COVID-19爆发期间发现的。在55名医务工作者中，21人已完全接种疫苗，另外3人接种了一剂疫苗。大多数病例（54/55）是由于变异B.1.1.7。接种疫苗和未接种疫苗的HCW在年龄、性别、获得部位、诊断时存在的症状和病毒载量方面没有显著差异。结论本研究发现在SARS-CoV-2变异株B.1.1.7感染的接种疫苗和未接种疫苗的HCW中病毒载量相似，表明BNT 162 b2预防B.1.1.7传播的效力可能降低。
Background Vaccination against COVID-19 is among the most effective measures to stop the spread of the disease. However, acceptance of vaccination against COVID-19 among HCWs has not been universal and emergence of new variants with increased transmissibility, reduced neutralization by BNT162b2 vaccine-elicited sera and ability to cause breakthrough infections in vaccinated individuals is concerning. The aim of this study was to compare viral load, clinical presentation at diagnosis and type of exposure among vaccinated (with BNT162b2) and non-vaccinated healthcare workers (HCWs). Methods Prospective cohort of HWCs diagnosed with COVID-19 by nasopharyngeal PCR from 4 January to 14 April. Viral loads were expressed by the cycle threshold (Ct) in PCR. Results During the study period 55 HCWs were found positive for SARS-CoV-2, most of whom (44/55) were identified from March 28 to April 14 during an in-hospital COVID-19 outbreak. Of the 55 HCWs, 21 were fully vaccinated and another three had received one dose. Most cases (54/55) were due to variant B.1.1.7. Vaccinated and unvaccinated HCWs did not differ significantly in regards to age, gender, site of acquisition, presence of symptoms at diagnosis and viral load. Conclusions This study found a similar viral load in vaccinated and non-vaccinated HCWs infected by SARS-CoV-2 variant B.1.1.7, suggesting potentially reduced efficacy of BNT162b2 in preventing transmission of B.1.1.7.