Remembering the past and imagining the future: Common and distinct neural substrates during event construction and elaboration
Remembering the past and imagining the future: Common and distinct neural substrates during event construction and elaboration
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DOI：
10.1016/j.neuropsychologia.2006.10.016
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发表时间：
2007-01-01
期刊：
影响因子：
2.6
通讯作者：
Schacter, Daniel L.
中科院分区：
文献类型：
--
作者：
Addis, Donna Rose;Wong, Alana T.;Schacter, Daniel L.
人们能够有意识地重新体验过去的事件，并预先体验可能的未来事件。这项功能性磁共振成像（fMRI）研究考察了介导过去和未来事件构建及细化的神经区域。参与者会看到一个名词提示20秒，并被要求在特定时间段（一周、一年、5 - 20年）内构建一个过去或未来的事件。一旦参与者在脑海中有了这个事件，他们就按下按钮，并在剩下的20秒内对事件进行细化。重要的是，所生成的所有事件都是情景性的，并且在一些现象学特征（细节、情感性、个人意义、场/观察者视角）上没有差异。联合分析表明，左侧海马体以及后部视觉空间区域在过去和未来事件构建中普遍参与，但在构建阶段也观察到了相当大的神经分化。未来事件招募了参与前瞻性思维和生成过程的区域，分别是右侧额极皮层和左侧腹外侧前额叶皮层。此外，未来事件构建独特地涉及右侧海马体，可能是对这些事件新颖性的一种反应。与构建阶段相反，细化阶段的特点是在构成自传体记忆检索网络的区域有显著重叠，这归因于细化过程中涉及的共同过程，包括自我参照加工、情境和情景意象。这种显著的神经重叠与失忆症患者在过去和未来思维方面都存在缺陷的发现是一致的，并证实情景系统对想象未来有重要贡献。（c）2006爱思唯尔有限公司。保留所有权利。
People can consciously re-experience past events and pre-experience possible future events. This fMRI study examined the neural regions mediating the construction and elaboration of past and future events. Participants were cued with a noun for 20s and instructed to construct a past or future event within a specified time period (week, year, 5-20 years). Once participants had the event in mind, they made a button press and for the remainder of the 20 s elaborated on the event. Importantly, all events generated were episodic and did not differ on a number of phenomenological qualities (detail, emotionality, personal significance, field/observer perspective). Conjunction analyses indicated the left hippocampus was commonly engaged by past and future event construction, along with posterior visuospatial regions, but considerable neural differentiation was also observed during the construction phase. Future events recruited regions involved in prospective thinking and generation processes, specifically right frontopolar cortex and left ventrolateral prefrontal cortex, respectively. Furthermore, future event construction uniquely engaged the right hippocampus, possibly as a response to the novelty of these events. In contrast to the construction phase, elaboration was characterized by remarkable overlap in regions comprising the autobiographical memory retrieval network, attributable to the common processes engaged during elaboration, including self-referential processing, contextual and episodic imagery. This striking neural overlap is consistent with findinas that amnesic patients exhibit deficits in both past and future thinking, and confirms that the episodic system contributes importantly to imagining the future. (c) 2006 Elsevier Ltd. All rights reserved.