Effect of electro-acupuncture at ST 36 on maternal food restriction-induced lung phenotype in rat offspring.
Effect of electro-acupuncture at ST 36 on maternal food restriction-induced lung phenotype in rat offspring.
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DOI：
10.1002/ppul.25466
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发表时间：
2021-08
影响因子：
3.1
通讯作者：
Rehan, Virender K.
中科院分区：
文献类型：
--
作者：
Mou, Qiujie;Ji, Bo;Zhao, Guozhen;Liu, Yitian;Sakurai, Reiko;Xie, Yana;Zhang, Qin;Dai, Jian;Lu, Yawen;Ge, Yunpeng;Shi, Tianyu;Xu, Shuang;Rehan, Virender K.
关键词：
孕期母体食物限制（MFR）会导致新生儿期肺部发育不良，并增加在生命后期患哮喘和慢性肺部疾病等疾病的易感性。先前的研究表明，对母体“足三里”（ST36）进行电针（EA）可防止关键的肺部发育信号通路异常表达，并改善围产期尼古丁暴露子代的肺部形态和功能。围产期尼古丁暴露和孕期母体食物限制所影响的肺部发育信号通路存在显著重叠；然而，母体在ST36进行电针是否也能阻断母体食物限制诱导的肺部表型尚不清楚。在此，我们研究了对母体ST36进行电针对肺部形态和功能以及关键的肺部发育信号通路表达的影响，以及与孕期母体食物限制相关的高皮质醇状态。将这些影响与美替拉酮（一种已知可阻断母体食物限制诱导的子代高皮质醇状态及由此产生的肺部病理改变的干预措施）的影响进行了比较。与美替拉酮一样，母体在ST36进行电针阻断了母体食物限制诱导的关键发育信号通路的改变，并保护了肺部形态和功能免受母体食物限制诱导的改变。这些结果为预防母体食物限制诱导的子代肺部发育不良提供了一种新颖、安全的非药物方法。
Maternal food restriction (MFR) during pregnancy leads to pulmonary dysplasia in the newborn period and increases susceptibility to diseases, such as asthma and chronic lung disease, later in life. Previous studies have shown that maternal electro-acupuncture (EA) applied to “Zusanli” (ST 36) could prevent the abnormal expression of key lung developmental signaling pathways and improve the lung morphology and function in perinatal nicotine exposed offspring. There is a significant overlap in lung developmental signaling pathways affected by perinatal nicotine exposure and MFR during pregnancy; however, whether maternal EA at ST 36 also blocks the MFR-induced lung phenotype is unknown. Here, we examined the effects of EA applied to maternal ST 36 on lung morphology and function and the expression of key lung developmental signaling pathways, and the hypercorticoid state associated with MFR during pregnancy. These effects were compared with those of metyrapone, an intervention known to block MFR-induced offspring hypercorticoid state and the resultant pulmonary pathology. Like metyrapone, maternal EA at ST 36 blocked the MFR-induced changes in key developmental signaling pathways and protected the MFR-induced changes in lung morphology and function. These results offer a novel and safe, non-pharmacologic approach to prevent MFR-induced pulmonary dysplasia in offspring.
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DOI：
10.1096/fj.202000985rr
发表时间：
2020-12
期刊：
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
影响因子：
--
作者：
Sreekantha S;Wang Y;Sakurai R;Liu J;Rehan VK
通讯作者：
Rehan VK
影响因子：
3.7
作者：
Menendez-Castro C;Fahlbusch F;Cordasic N;Amann K;Münzel K;Plank C;Wachtveitl R;Rascher W;Hilgers KF;Hartner A
通讯作者：
Hartner A
影响因子：
7.2
作者：
通讯作者：
--
影响因子：
4.3
作者：
Bao, Chun-Hui;Wang, Chun-Ye;Wu, Huan-Gan
通讯作者：
Wu, Huan-Gan
影响因子：
24.3
作者：
Louzada, Ruy Andrade;Corre, Raphael;Dupuy, Corinne
通讯作者：
Dupuy, Corinne