MR SIGNAL ABNORMALITIES AT 1.5-T IN ALZHEIMER DEMENTIA AND NORMAL AGING
MR SIGNAL ABNORMALITIES AT 1.5-T IN ALZHEIMER DEMENTIA AND NORMAL AGING
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DOI：
10.2214/ajr.149.2.351
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发表时间：
1987-08-01
影响因子：
5
通讯作者：
ZIMMERMAN, RA
中科院分区：
文献类型：
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作者：
FAZEKAS, F;CHAWLUK, JB;ZIMMERMAN, RA
阿尔茨海默病和正常衰老的MR信号异常的类型、频率和程度是一个有争议的话题。使用1.5-MR装置，我们研究了12名阿尔茨海默病患者，4名患有多发性梗死性痴呆的受试者和9名年龄匹配的对照者。在60%的阿尔茨海默病患者和对照组中，深部白色物质的点状或早期融合性高信号异常与高血压或其他血管危险因素无关。与对照组相比，显著数量的阿尔茨海默病患者表现出更广泛的室周高信号平滑“晕”（p = 0.024）。广泛的深部白质高信号（2例）和广泛的，不规则的脑室周围高信号（3例）被认为是多发梗塞性痴呆。影响海马和侧裂皮层的高信号强度区域也存在于5名阿尔茨海默病和2名多发性梗死性痴呆患者中，但在对照组中不存在。离散的、小的深部白质高信号灶不是阿尔茨海默病的特征，也不意味着痴呆疾病的血管原因。在阿尔茨海默病中经常观察到的室周高信号的“晕”可能具有诊断意义。特定皮质区域的高信号异常可能反映了局限于这些结构的疾病过程。
The type, frequency, and extent of MR signal abnormalities in Alzheimer''s disease and normal aging are a subject of controversy. With a 1.5-MR unit we studied 12 Alzheimer patients, four subjects suffering from multiinfarct dementia and nine age-matched controls. Punctate or early confluent high-signal abnormalities in the deep white matter, noted in 60% of both Alzheimer patients and controls, were unrelated to the presence of hypertension or other vascular risk factors. A significant number of Alzheimer patients exhibited a more extensive smooth "halo" of periventricular hyperintensity when compared with controls (p = .024). Widespread deep white-matter hyperintensity (two patients) and extensive, irregular periventricular hyperintensity (three patients) were seen in multiinfarct dementia. Areas of high signal intensity affecting hippocampal and sylvian cortex were also present in five Alzheimer and two multiinfarct dementia patients, but absent in controls. Discrete, small foci of deep white-matter hyperintensity are not characteristic of Alzheimer''s disease nor do they appear to imply a vascular cause for the dementing illness. The frequently observed "halo" of periventricular hyperintensity in Alzheimer''s disease may be of diagnostic importance. High-signal abnomalities in specific cortical regions are likely to reflect disease processes localized to those structures.