Electroanalysis of Natural Compounds as Copper Chelating Agents for Alzheimer's Disease Therapy
Electroanalysis of Natural Compounds as Copper Chelating Agents for Alzheimer's Disease Therapy
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DOI：
10.1002/elan.201500138
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发表时间：
2015-11-01
期刊：
影响因子：
3
通讯作者：
Kerman, Kagan
中科院分区：
文献类型：
--
作者：
Hung, Vinci Wing Sze;Bressan, Lucas Paines;Kerman, Kagan
开发能够减弱由金属离子积累所产生的毒性的治疗性化合物一直是神经退行性疾病的深入研究领域。在这份报告中，电化学方法开发，以确定铜（II）-螯合能力的多酚，有牵连的阿尔茨海默氏病（AD）。结果表明，黄酮类化合物对Cu（II）的螯合作用大小为表没食子儿茶素没食子酸酯（EGCG）>白藜芦醇>氯碘羟喹>黄芩素，与鲨肌醇相似。此外，羟基基团的数量被发现发挥作用，以降低铜（II）的氧化信号，使用差分脉冲伏安法。
The development of therapeutic compounds that can attenuate the toxicity exerted by the accumulation of metal ions has been an area of intensive research in neurodegenerative diseases. In this report, an electrochemical method was developed to determine the Cu(II)-chelating ability of polyphenols that were implicated in Alzheimer's disease (AD). The results suggested the strength of flavonoids to chelate Cu(II) as epigallocatechin-3-gallate (EGCG)> resveratrol> clioquinol> baicalein similar to scyllo-inositol. Furthermore, the number of hydroxyl groups was found to play a role to lower Cu(II) oxidation signal using differential pulse voltammetry.