Aging-related changes in fluid intelligence, muscle and adipose mass, and sex-specific immunologic mediation: A longitudinal UK Biobank study.
Aging-related changes in fluid intelligence, muscle and adipose mass, and sex-specific immunologic mediation: A longitudinal UK Biobank study.
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DOI：
10.1016/j.bbi.2019.09.008
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发表时间：
2019-11
期刊：
影响因子：
--
通讯作者：
Willette AA
中科院分区：
文献类型：
--
作者：
Klinedinst BS;Pappas C;Le S;Yu S;Wang Q;Wang L;Allenspach-Jorn K;Mochel JP;Willette AA
Obesity in midlife and early late-life is associated with worse normal cognitive aging. Dual-energy x-ray absorptiometry (DEXA) suggests that visceral adipose mass (VAM) plays a predominant role, whereas non-visceral adipose mass (NVAM) and lean muscle mass (LMM) have shown conflicting relationships. It is unknown how longitudinal, cognitive changes in age-sensitive domains like fluid intelligence (FI) correspond to VAM, NVAM, and LMM in women and men. Furthermore, changes over time in blood leukocyte sub-populations may partially or fully account for sex-specific associations. Data on 4,431 late middle-aged, cognitively unimpaired adults (mean=64.5y) was obtained from the UK Biobank prospective cohort across 22 centers. FI scores, blood leukocyte counts, and covariates (age, social class, education) were measured at three 2-year intervals over 6 years. DEXA collection overlapped with these intervals. Sex-stratified growth curves, structural equations, and Preacher-Hayes mediation were used to estimate direct and indirect effects. β-weights were standardized. More LMM predicted gains in FI scores among women (β=.130, p<.001) and men (β=.089, p<.001). Conversely, more VAM and NVAM independently predicted FI decline equally among sexes (e.g., NVAM: women: β=−.082, p<.001; men: β=−.076, p<.001). Among women, FI associations were fully mediated by higher eosinophil counts via VAM (λ=30.8%, p=.028) and lower lymphocyte counts via LMM (λ=69.2%, p=.021). Among men, FI associations were partially mediated by lower basophils counts via LMM (λ=4.5%, p=.042) and higher counts via VAM (λ=50%, p=.037). The proportion of LMM and VAM equally influenced male FI changes over 6 years, whereas higher LMM among women appeared to more strongly influence FI changes. Leukocyte counts strongly mediated VAM- and LMM-related FI changes in a sex-specific manner, but not for NVAM. For clinical translation, exercise studies in older adults may benefit from assessing sex-specific values of DEXA-based tissue mass, FI, and leukocyte sub-populations to gauge potential cognitive benefits of less VAM and more LMM.
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影响因子：
4.6
作者：
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