Prevalence of metabolic syndrome assessed by IDF and NCEP ATP 111 criteria and determinants of insulin resistance among HIV patients in the Eastern Cape Province of South Africa
Prevalence of metabolic syndrome assessed by IDF and NCEP ATP 111 criteria and determinants of insulin resistance among HIV patients in the Eastern Cape Province of South Africa
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DOI：
10.1016/j.dsx.2010.09.002
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发表时间：
2010-10-01
影响因子：
10
通讯作者：
Iputo, J.
中科院分区：
文献类型：
--
作者：
Awotedu, K.;Ekpebegh, C.;Iputo, J.
目的：了解HIV感染者在接受抗逆转录病毒治疗（ART）、ART初治和HIV阴性患者中代谢综合征（MS）和胰岛素抵抗（IR）的患病率及其影响因素。结果：经抗逆转录病毒治疗的HIV感染者、未经抗逆转录病毒治疗的HIV感染者和HIV阴性者MS患病率分别为26.6%、15.7%和21.9%（P = 0.3）。接受抗逆转录病毒治疗的HIV患者、未接受抗逆转录病毒治疗的HIV患者和HIV阴性患者中，符合IDF定义的MS发生率分别为22.7%、23.2%和19.3%（P = 0.8）。接受ART治疗的HIV患者中，IDF标准的腰围增加（P = 0.03）、内脏与皮下脂肪比（P = 0.049）、高甘油三酯血症（P < 0.001）和高LDL-胆固醇（P < 0.001）比其他组更常见。ART组、ART初治组和HIV阴性组的IR发生率分别为12.8%、3.6%和2.4%（P = 0.003）。男性性别（比值比（OR）11 95%CI 3-48; P < 0.001）与MS独立相关。（OR 6.6 95% CI 1.3-32.3; P = 0.020），MS的IDF定义（OR 3.4 95% CI 1.1-10.7; P = 0.040），MS的NCEP定义（OR 3.2 95% CI 1.01-10.3; P = 0.049）和低HDL-胆固醇（OR 5.7 95%CI 1.2-27; P = 0.029）与IR独立相关。结论：采用IDF和NCEP定义的MS患病率在各组间相似。接受ART和MS的HIV患者与IR独立相关，而男性与MS独立相关。（C）2010年印度糖尿病。由爱思唯尔有限公司出版。保留所有权利。
Aims: To determine the prevalence of metabolic syndrome ( MS) and insulin resistance (IR) and their determinants in HIV on ART, ART naive HIV and HIV negative patients.Methods: Cross sectional study. ART experienced HIV, ART naive HIV and HIV negative patients were compared for differences in prevalence of MS and IR. Determinants of MS and IR were assessed.Results: Prevalence of MS by NCEP criteria was 26.6%, 15.7% and 21.9% (P = 0.3) respectively for HIV on ART, ART naive HIV and HIV negative groups. The MS rates with the IDF definition were 22.7%, 23.2% and 19.3% (P = 0.8) for HIV on ART, ART naive HIV and HIV negative patients respectively. Increased waist circumference by IDF criteria (P = 0.03), visceral to subcutaneous fat ratio (P = 0.049), hypertriglyceredemia (P < 0.001) and high LDL-Cholesterol (P < 0.001) were more common in HIV patients on ART than other groups. IR was found in 12.8%, 3.6% and 2.4% (P = 0.003) of HIV on ART, ART naive HIV and HIV negative groups respectively. Male gender (odds ratio (OR) 11 95% CI 3-48; P < 0.001) was independently associated with MS. HIV patients on ART (OR 6.6 95% CI 1.3-32.3; P = 0.020), IDF definition of MS (OR 3.4 95% CI 1.1-10.7; P = 0.040), NCEP definition of MS (OR 3.2 95% CI 1.01-10.3; P = 0.049) and low HDL-Cholesterol (OR 5.7 95% CI 1.2-27; P = 0.029) were independently associated with IR.Conclusion: Prevalence of MS with IDF and NCEP definitions was similar across groups. HIV patients on ART and MS were independently associated with IR while male gender was independently associated with MS. (C) 2010 Diabetes India. Published by Elsevier Ltd. All rights reserved.