Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes
Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes
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DOI：
10.1016/j.bbrc.2006.05.170
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发表时间：
2006-08-04
影响因子：
3.1
通讯作者：
Kim, Jae Bum
中科院分区：
文献类型：
--
作者：
Song, Min Jeong;Kim, Kang Ho;Kim, Jae Bum
慢性炎症与代谢紊乱（如肥胖和2型糖尿病）密切相关，但其潜在机制尚不清楚。toll样受体（TLRs）在先天免疫反应和炎症信号中发挥关键作用。在此，我们观察到肥胖db/db小鼠脂肪组织中TLR4 mRNA水平在脂肪细胞分化过程中被诱导并显著增强。此外，LPS或游离脂肪酸激活TLR4可刺激NF κ B信号传导和炎性细胞因子基因的表达，如3T3-L1脂肪细胞中的TNF α和IL-6。此外，我们发现TLR4在3T3-L1脂肪细胞中的激活会引起胰岛素抵抗。综上所述，这些结果表明，脂肪细胞中TLR4的激活可能与肥胖和2型糖尿病中胰岛素抵抗的发生有关。(c) 2006爱思唯尔公司版权所有。
Chronic inflammation is closely associated with metabolic disorders such as obesity and type 2 diabetes, however, the underlying mechanism is unclear. Toll-like receptors (TLRs) play a key role in innate immune response as well as inflammatory signals. Here, we observed that mRNA level of TLR4 was induced during adipocyte differentiation and remarkably enhanced in fat tissues of obese db/db mice. In addition, activation of TLR4 with either LPS or free fatty acids stimulated NF kappa B signaling and expression of inflammatory cytokine genes, such as TNF alpha and IL-6 in 3T3-L1 adipocytes. Furthermore, we discovered that TLR4 activation in 3T3-L1 adipocytes provoked insulin resistance. Taken together, these results suggest that activation of TLR4 in adipocyte might be implicated in the onset of insulin resistance in obesity and type 2 diabetes. (c) 2006 Elsevier Inc. All rights reserved.