Metal Complexes, an Untapped Source of Antibiotic Potential?
Metal Complexes, an Untapped Source of Antibiotic Potential?
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DOI：
10.3390/antibiotics9020090
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发表时间：
2020-02-01
影响因子：
4.8
通讯作者：
Frei, Angelo
中科院分区：
文献类型：
--
作者：
Frei, Angelo
随着抗菌素耐药性的普遍上升，大多数传统的新药化合物来源已被广泛探索，以寻找新的抗生素类别。与此同时，金属络合物长期以来在药物化学领域只有一个利基存在，尽管一些化合物，如抗癌药物顺铂，已经产生了深远的影响，并在今天仍被广泛用于癌症治疗。事实上，在抗生素开发中，金属络合物在很大程度上被忽视了。这是令人惊讶的，因为金属化合物可以获得独特的作用模式，并存在于比纯有机化合物更广泛的三维几何图形中。这些特性使它们成为开发新药的有趣起点。在这篇观点文章中，重点介绍了主要在过去十年中在抗菌金属络合物方面所做的令人鼓舞的工作。讨论了有前景的金属络合物、它们的活性分布和可能的作用模式，并强调了有待解决的问题。
With the widespread rise of antimicrobial resistance, most traditional sources for new drug compounds have been explored intensively for new classes of antibiotics. Meanwhile, metal complexes have long had only a niche presence in the medicinal chemistry landscape, despite some compounds, such as the anticancer drug cisplatin, having had a profound impact and still being used extensively in cancer treatments today. Indeed, metal complexes have been largely ignored for antibiotic development. This is surprising as metal compounds have access to unique modes of action and exist in a wider range of three-dimensional geometries than purely organic compounds. These properties make them interesting starting points for the development of new drugs. In this perspective article, the encouraging work that has been done on antimicrobial metal complexes, mainly over the last decade, is highlighted. Promising metal complexes, their activity profiles, and possible modes of action are discussed and issues that remain to be addressed are emphasized.