Cellular biology of fracture healing.
Cellular biology of fracture healing.
复制标题
DOI：
10.1002/jor.24170
复制
发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Hankenson KD
中科院分区：
文献类型：
--
作者：
Bahney CS;Zondervan RL;Allison P;Theologis A;Ashley JW;Ahn J;Miclau T;Marcucio RS;Hankenson KD
The biology of bone healing is a rapidly developing science. Advances in transgenic and gene-targeted mice have enabled tissue and cell-specific investigations of skeletal regeneration. As an example, only recently has it been recognized that chondrocytes convert to osteoblasts during healing bone, and only several years prior, seminal publications reported definitively that the primary tissues contributing bone forming cells during regeneration were the periosteum and endosteum. While genetically modified animals offer incredible insights into the temporal and spatial importance of various gene products, the complexity and rapidity of healing— coupled with the heterogeneity of animal models—renders studies of regenerative biology challenging. Herein, cells that play a key role in bone healing will be reviewed and extracellular mediators regulating their behavior discussed. We will focus on recent studies that explore novel roles of inflammation in bone healing, and the origins and fates of various cells in the fracture environment.
登录
查看更多内容
DOI：
10.1002/jbmr.2287
发表时间：
2014-12
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Chen H;Ghori-Javed FY;Rashid H;Adhami MD;Serra R;Gutierrez SE;Javed A
通讯作者：
Javed A
影响因子：
15.8
作者：
Chen Y;Whetstone HC;Lin AC;Nadesan P;Wei Q;Poon R;Alman BA
通讯作者：
Alman BA
影响因子：
--
作者：
Adams, J. M.;Difazio, L. T.;Nemeth, Z. H.
通讯作者：
Nemeth, Z. H.
影响因子：
6.2
作者：
Barnes, GL;Kostenuik, PJ;Einhorn, TA
通讯作者：
Einhorn, TA
DOI：
10.1073/pnas.0504750102
发表时间：
2005-10-11
影响因子：
11.1
作者：
Akiyama, H;Kim, JE;de Crombrugghe, B
通讯作者：
de Crombrugghe, B