Anterior cingulate synapses in prefrontal areas 10 and 46 suggest differential influence in cognitive control.
Anterior cingulate synapses in prefrontal areas 10 and 46 suggest differential influence in cognitive control.
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DOI：
10.1523/jneurosci.1773-10.2010
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发表时间：
2010-12-01
期刊：
影响因子：
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通讯作者：
Barbas H
中科院分区：
文献类型：
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作者：
Medalla M;Barbas H
背外侧前额叶区46和10参与认知的不同方面。46区在工作记忆任务中起着关键作用，而额极区10则在复杂的多任务操作中被招募。这两个区域都受前扣带皮层（ACC）的支配，ACC是一个与情绪和记忆相关的区域，但通过未知的突触机制对注意力控制也很重要。在这里，我们发现，在恒河猴（猕猴）标记的示踪剂注射在ACC区32支配的棘假定兴奋性神经元的轴突终末，但约20-30%的大多数形成大突触与树突轴假定抑制性神经元的上层（I-IIIa）的背外侧区10，46和9。此外，区域32终端优先针对钙结合蛋白，并在较小程度上，calretinin神经元，这被认为是抑制性神经元，调节增益的任务相关的活动在工作记忆任务。在假定的抑制性神经元上，46区被区分为更多（约40%）32区突触的受体。区域10在假定的兴奋性神经元的棘上作为显著更大（体积约为40%）的区域32末端的受体。这些突触特化表明，32区具有互补作用，可能会增强46区的抑制和10区的兴奋，这可能有助于将注意力引导到新任务上，同时暂时记住另一项任务。
Dorsolateral prefrontal areas 46 and 10 are involved in distinct aspects of cognition. Area 46 has a key role in working memory tasks, and frontopolar area 10 is recruited in complex multi-task operations. Both areas are innervated by the anterior cingulate cortex (ACC) a region associated with emotions and memory, but is also important for attentional control through unknown synaptic mechanisms. Here we found that in rhesus monkeys (Macaca mulatta) most axon terminals labeled from tracers injected in ACC area 32 innervated spines of presumed excitatory neurons, but about 20–30% formed mostly large synapses with dendritic shafts of presumed inhibitory neurons in the upper layers (I–IIIa) of dorsolateral areas 10, 46, and 9. Moreover, area 32 terminals targeted preferentially calbindin and, to a lesser extent, calretinin neurons, which are thought to be inhibitory neurons that modulate the gain of task-relevant activity during working memory tasks. Area 46 was distinguished as recipient of more (by ~40%) area 32 synapses on putative inhibitory neurons. Area 10 stood apart as recipient of significantly larger (by ~40% in volume) area 32 terminals on spines of putative excitatory neurons. These synaptic specializations suggest that area 32 has complementary roles, potentially enhancing inhibition in area 46 and strengthening excitation in area 10, which may help direct attention to new tasks while temporarily holding in memory another task.