Hippocampal area metabolites relate to severity and cognitive function in obstructive sleep apnea
Hippocampal area metabolites relate to severity and cognitive function in obstructive sleep apnea
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DOI：
10.1016/j.sleep.2004.08.004
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发表时间：
2004-11-01
期刊：
影响因子：
4.8
通讯作者：
Grunstein, RR
中科院分区：
文献类型：
--
作者：
Bartlett, DJ;Rae, C;Grunstein, RR
背景和目的：阻塞性睡眠呼吸暂停（OSA）与间歇性缺氧和认知能力下降有关。由于海马体对缺氧特别敏感，我们假设它可能表现出生化异常，而这些异常可能与呼吸暂停的严重程度有关。患者和方法：8名男性OSA患者和5名年龄相匹配的对照组，在所有受试者的左海马区获得多导睡眠图和质子磁共振波谱前后进行神经认知测试。结果：OSA患者左海马区含n -乙酰基/含肌酸化合物显著升高（P = 0.04）。对这些化合物的水共振检查表明，这很可能是由于含肌酸化合物的减少，而不是由于含n -乙酰基化合物的任何变化。海马含肌酸化合物水平较低与更严重的OSA严重程度和神经认知表现相关。结论：我们认为海马区肌酸水平的变化代表了脑生物能量学的调整，类似于缺血预处理，并可能反映了这些组织对OSA缺氧损伤的不同易感性。(C) 2004 Elsevier B.V.版权所有
Background and purpose: Obstructive sleep apnea (OSA) is associated with intermittent hypoxia and cognitive decrements. As the hippocampus is particularly susceptible to hypoxia, we hypothesized that it may show biochemical abnormalities, and they may relate to apnea severity.Patients and methods: Eight males with OSA and five age-matched controls underwent neurocognitive testing before and after polysomnography and proton magnetic resonance spectra were obtained from the left hippocampal area of all subjects.Results: In the left hippocampal area, N-acetyl-containing/creatine-containing compounds was significantly increased in OSA (P = 0.04). Inspection of these compounds with respect to the water resonance indicated that this was most likely due to a decrease in creatine-containing compounds rather than any change in N-acetyl-containing compounds. Lower levels of hippocampal creatine-containing compounds were correlated with worse OSA severity and neurocognitive performance.Conclusions: We suggest the changes in creatine levels in the hippocampal area represent adjustments to brain bioenergetics, similar to those seen in ischemic preconditioning, and may reflect the different susceptibility of these tissues to hypoxic damage in OSA. (C) 2004 Elsevier B.V. All rights reserved.