LACK OF ASSOCIATION BETWEEN ESSENTIAL TREMOR AND PARKINSONS-DISEASE
LACK OF ASSOCIATION BETWEEN ESSENTIAL TREMOR AND PARKINSONS-DISEASE
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DOI：
10.1002/ana.410240106
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发表时间：
1988-07-01
影响因子：
11.2
通讯作者：
KOLLER, W
中科院分区：
文献类型：
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作者：
CLEEVES, L;FINDLEY, LJ;KOLLER, W
研究了特发性震颤（ET）和帕金森病（PD）之间可能相关的四个方面：（1）ET中锥体外系体征的频率;（2）同时发生ET和PD的频率（即，PD发作前5年或更长时间的单症状姿势性震颤）;（3）PD患者家族中ET的频率;和（4）ET患者家族中PD的频率。对237例ET患者（伦敦137例，芝加哥100例）进行了评价。100例PD患者和100名正常对照者也进行了调查。轻度锥体外系体征仅发生在4.5%的ET患者中，与正常衰老中发现的体征一致。只有3%的PD患者有单纯性ET病史。ET患者、一组患者和对照受试者之间PD家族史的频率没有差异。PD患者中ET家族史的频率高于对照组，但差异无统计学意义。这些数据表明ET和PD之间没有关联或遗传联系。
Four aspects of a possible association between essential tremor (ET) and Parkinson''s disease (PD) were investigated: (1) the frequency of extrapyramidal signs in ET; (2) the frequency of concurrent ET and PD (i.e., monosymptomatic postural tremor for 5 or more years prior to onset of PD); (3) the frequency of ET in the families of PD patients; and (4) the frequency of PD in families of ET patients. Two hundred and thirty-seven ET patients (137 in London and 100 in Chicago) were evaluated. One hundred patients with PD and 100 normal control subjects were also investigated. Mild extrapyramidal signs occurred in only 4.5% of ET patients and were consistent with those found in normal aging. Only 3% of PD patients gave a history of uncomplicated ET. There was no difference in the frequency of a family history of PD between ET patients, a group of patients, and control subjects. Frequency of a family history of ET was higher among PD patients than control subjects, although the difference was not statistically significant. These data indicate that there is no association or genetic link between ET and PD.