The plasma level changes of VEGF and soluble VEGF receptor-1 are associated with high-altitude pulmonary edema.
The plasma level changes of VEGF and soluble VEGF receptor-1 are associated with high-altitude pulmonary edema.
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DOI：
10.2152/jmi.65.64
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Wu S
中科院分区：
文献类型：
--
作者：
Zhang S;Liu J;Jiang D;Wuren T;Ma S;Du Y;Yi X;Wu S
缺氧诱导的VEGF和sFlt-1的血浆水平是导致脑和肺水肿中发生的血管通透性增加的原因。目前，VEGF和sFlt-1在高原肺水肿（HAPE）发病机制中的确切作用尚不清楚。在这项研究中，从10个HAPE和10个非HAPE受试者的血浆VEGF和sFlt-1的水平进行了测量和比较。结果显示，与非HAPE组相比，HAPE患者中VEGF和sFlt-1的血浆水平均显著升高。有趣的是，这两种蛋白质因子的血浆水平在治疗后显著降低。与VEGF相比，sFlt-1受缺氧和治疗的影响更大，提示sFlt-1是HAPE发病的关键因素。重要的是，无论是非HAPE组还是HAPE组恢复后sFlt-1和VEGF的比值均显著低于HAPE患者治疗前的比值。提示sFlt-1是HAPE发病的关键因素，sFlt-1/VEGF比值可作为HAPE的敏感诊断指标。
Hypoxia-induced plasma levels of VEGF and sFlt-1 are responsible for increased vascular permeability occurred in both brain and pulmonary edema. Currently, it remains unclear the exact roles of VEGF and sFlt-1 in High Altitude Pulmonary Edema (HAPE) pathogenesis. In this study, plasma levels of VEGF and sFlt-1 from 10 HAPE and 10 non-HAPE subjects were measured and compared. The results showed that plasma levels of both VEGF and sFlt-1 in HAPE patients were significantly increased as compared to the non-HAPE group. Interestingly, increased plasma levels of these two protein factors were markedly reduced after treatments. As compared to VEGF, sFlt-1 was much more affected by hypoxia and treatments, suggesting this factor was a key factor contributed to HAPE pathogenesis. Importantly, the ratio of sFlt-1 and VEGF in group of either non-HAPE or HAPE after recovery was significantly lower than the ratio in HAPE patients prior to treatments. Our findings suggested that sFlt-1 was a key factor that involved in HAPE pathogenesis and the sFlt-1/VEGF ratio could be used as a sensitive diagnostic marker for HAPE.