Asymmetric Morita-Baylis-Hillman Reaction Catalyzed by Simple Amino Alcohol Derived Thioureas
Asymmetric Morita-Baylis-Hillman Reaction Catalyzed by Simple Amino Alcohol Derived Thioureas
复制标题
简单氨基醇硫脲催化的不对称 Morita-Baylis-Hillman 反应
作者：
A. Lattanzi
已发现直接衍生自市售对映体纯氨基醇的硫脲促进2-环己烯-1-酮和不同醛在三乙胺存在下在无溶剂条件下的不对称Morita-Baylis-Hillman反应。相应的烯丙醇得到了良好的高产率和高达88%ee。
Thioureas straightforwardly derived from commercially available enantiopure amino alcohols have been found to promote the asymmetric Morita-Baylis-Hillman reaction of 2-cyclohexen-1-one and different aldehydes in the presence of triethylamine under solvent-free conditions. The corresponding allylic alcohols were obtained in good to high yields and up to 88% ee.