Anti-Mullerian hormone and anti-Mullerian hormone type II receptor polymorphisms are associated with follicular phase estradiol levels in normo-ovulatory women
Anti-Mullerian hormone and anti-Mullerian hormone type II receptor polymorphisms are associated with follicular phase estradiol levels in normo-ovulatory women
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DOI：
10.1093/humrep/dem036
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发表时间：
2007-06-01
影响因子：
6.1
通讯作者：
Visser, Jenny A.
中科院分区：
文献类型：
--
作者：
Kevenaar, Marlies E.;Themmen, Axel P. N.;Visser, Jenny A.
背景：在小鼠中，抗苗勒管激素（AMH）抑制原始卵泡募集并降低卵泡刺激素敏感性。人们对AMH在人类卵巢生理中的作用知之甚少。我们假设在女性中AMH在卵巢功能中具有与小鼠相似的作用，并使用遗传方法对此进行了研究。方法：在荷兰（n = 32）和德国（n = 21）正常排卵女性队列中研究AMH Ile (49)Ser和AMH型H受体(AMHR2) -482 A > G多态性与月经周期特征的关系。结果：AMH Ser（49）等位基因携带者在月经周期第3天的血清雌二醇（E-2）水平高于荷兰队列（P = 0.012）和荷兰和德国联合队列（P = 0.03）的非携带者。与荷兰队列（P = 0.028）、德国队列（P = 0.048）以及联合队列（P = 0.012）中的非携带者相比，AMHR2 -482G等位基因携带者的卵泡期E2水平也更高。同时携带AMH Ser（49）和AMHR2 -482G等位基因的女性e2水平最高（P = 0.001）。两种多态性均与血清AMH或FSH水平无相关性。结论：AMH和AMHR2基因多态性与卵泡E-2期水平相关，提示AMH在调节人卵巢FSH敏感性中发挥作用。
BACKGROUND: In mice, anti-Mullerian hormone (AMH) inhibits primordial follicle recruitment and decreases FSH sensitivity. Little is known about the role of AMH in human ovarian physiology. We hypothesize that in women AMH has a similar role in ovarian function as in mice and investigated this using a genetic approach. METHODS: The association of the AMH Ile (49)Ser and the AMH type H receptor (AMHR2) -482 A > G polymorphisms with menstrual cycle characteristics was studied in a Dutch (n = 32) and a German (n = 21) cohort of normo-ovulatory women. RESULTS: Carriers of the AMH Ser(49) allele had higher serum estradiol (E-2) levels on menstrual cycle day 3 when compared with non-carriers in the Dutch cohort (P = 0.012) and in the combined Dutch and German cohort (P = 0.03). Carriers of the AMHR2 -482G allele also had higher follicular phase E2 levels when compared with non-carriers in the Dutch cohort (P = 0.028), the German cohort (P = 0.048) and hence also the combined cohort (P = 0.012). Women carrying both AMH Ser(49) and AMHR2 -482G alleles had highest E-2 levels (P = 0.001). For both polymorphisms no association with serum AMH or FSH levels was observed. CONCLUSIONS: Polymorphisms in the AMH and AMHR2 genes are associated with follicular phase E-2 levels, suggesting a role for AMH in the regulation of FSH sensitivity in the human ovary.