Axonally translated SMADs link up BDNF and retrograde BMP signaling.
Axonally translated SMADs link up BDNF and retrograde BMP signaling.
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轴突翻译的 SMAD 连接 BDNF 和逆行 BMP 信号传导。
DOI：
10.1016/j.neuron.2012.03.012
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发表时间：
2012
期刊：
影响因子：
16.2
通讯作者：
Wang,Fan
中科院分区：
文献类型：
--
作者：
Takatoh,Jun;Wang,Fan
已知轴突靶源性BMP和神经营养因子信号都调节神经元基因表达、分化和轴突生长。在本期《神经元》中，Ji和Jaffrey（2012）发现bmp信号内体依赖bdnf诱导的轴突合成smad逆行调节发育中的三叉神经细胞的转录，提供了一种整合两种靶标来源信号的机制。
Axonal target-derived BMP and neurotrophin signaling are both known to regulate neuronal gene expression, differentiation, and axon growth. In this issue ofNeuron, Ji and Jaffrey (2012) discovered that BMP-signaling endosomes depend on BDNF-induced axonal synthesis of SMADs to retrogradely regulate transcription in developing trigeminal neurons, providing a mechanism of integrating the two target-derived signals.