One-year results of reduced fluence photodynamic therapy for central serous chorioretinopathy: the outer nuclear layer thickness is associated with visual prognosis
One-year results of reduced fluence photodynamic therapy for central serous chorioretinopathy: the outer nuclear layer thickness is associated with visual prognosis
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DOI：
10.1007/s00417-013-2289-4
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发表时间：
2013-08-01
影响因子：
2.7
通讯作者：
Tsuneoka, Hiroshi
中科院分区：
文献类型：
--
作者：
Ohkuma, Yasuhiro;Hayashi, Takaaki;Tsuneoka, Hiroshi
评价低通量光动力疗法（RFPDT）治疗中枢性浆液性脉络膜视网膜病变（CSC）的疗效。本研究回顾了连续接受RFPDT（全剂量维替泊芬和25 J/cm(2)激光能量）治疗的CSC患者的病历，检查了21例患者的22只眼睛（20名男性和1名女性）。所有患者均随访1年。在初始RFPDT后的基线、1、3、6、9和12个月评估最佳矫正视力（BCVA）、视网膜下液完全分辨率（CR of SRF）、视网膜中央厚度（CRT）、外核层厚度（ONL）和光感受器内外段（IS/OS）线。在12个月期间，所有病例均进行了一次RFPDT治疗。所有患者均确定SRF的CR。3 ~ 12个月时BCVA明显改善（P < 0.05）。CRT在1至12个月内显著下降。1个月时，ONL明显变厚，17只眼（77.2%）恢复了连续的中央凹IS/OS线。ONL厚度与12月时BCVA相关（P < 0.01）。逐步分析显示，治疗前BCVA （P < 0.01）和ONL厚度（P < 0.01）是12个月BCVA的显著预测因素。在随访期间没有观察到眼部和全身的不良反应。RFPDT是一种有效的治疗CSC的方法。ONL厚度是CSC RFPDT的重要视觉预测因子。
To evaluate the efficacy of reduced-fluence photodynamic therapy (RFPDT) for central serous chorioretinopathy (CSC).This retrospective medical record review of consecutive CSC patients treated with RFPDT (full-dose verteporfin and laser fluence of 25 J/cm(2)) examined 22 eyes of 21 patients (20 males and one female). All patients were followed-up for 1 year. Best-corrected visual acuity (BCVA), complete resolution of subretinal fluid (CR of SRF), central retinal thickness (CRT), the outer nuclear layer (ONL) thickness, and the photoreceptor inner and outer segments (IS/OS) line determined by optical coherence tomography imaging were evaluated at baseline, 1, 3, 6, 9, and 12 months after initial RFPDT.A single RFPDT session was performed in all cases during a 12-month period. CR of SRF was identified in all patients. BCVA significantly improved between 3 and 12 months (P < 0.05). The CRT significantly decreased between 1 and 12 months. A significantly thicker ONL was observed at 1 month, and 17 eyes (77.2 %) showed recovery of the continuous foveal IS/OS line. ONL thickness was correlated with BCVA at 12 months (P < 0.01). Stepwise analysis indicated that pre-treatment BCVA (P < 0.01) and ONL thickness (P < 0.01) were significant predictive factors for BCVA at 12 months. Neither ocular nor systemic adverse effects were observed during the follow-up period.RFPDT appears to be an effective treatment method for CSC. ONL thickness is an important visual predictive factor of RFPDT for CSC.