Dermal penetration of bisphenol A in human skin contributes marginally to total exposure
Dermal penetration of bisphenol A in human skin contributes marginally to total exposure
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DOI：
10.1016/j.toxlet.2012.07.001
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发表时间：
2012-09-18
影响因子：
3.5
通讯作者：
Bourqui-Pittet, Martine
中科院分区：
文献类型：
--
作者：
Demierre, Anne-Laure;Peter, Ronald;Bourqui-Pittet, Martine
双酚A（BPA）是普遍存在的，在过去的几十年中，已经描述了许多接触场景。虽然口服摄入被认为是主要的接触途径，但最近讨论了皮肤渗透的作用。在本研究中，根据OECD试验指南428，采用体外试验方法测定了BPA在人体皮肤中的皮肤渗透率。该分析导致在实际暴露条件下孵育24小时后，渗透率为8.6%，生物可利用BPA总量为所用剂量的9.3%。这证实了通过皮肤全身暴露于BPA对全身BPA暴露的贡献可以忽略不计。(c)2012爱思唯尔爱尔兰有限公司保留所有权利。
Bisphenol A (BPA) is ubiquitous and many exposure scenarios have been described during the last decades. While oral uptake is considered as the major route of exposure, the contribution of skin penetration has been recently discussed. In the present study, the dermal penetration rate of BPA has been determined in human skin in an in vitro test method according to the OECD Test Guideline 428. This analysis resulted in penetration of 8.6% and a total amount of bio-available BPA of 9.3% of the dose applied after 24 h incubation under realistic exposure conditions. This confirms that the systemic exposure to BPA via the skin contributes in a negligible way to total systemic BPA exposure. (c) 2012 Elsevier Ireland Ltd. All rights reserved.