Disrupted white matter connectivity is associated with reduced cortical thickness in the cingulate cortex in schizophrenia
Disrupted white matter connectivity is associated with reduced cortical thickness in the cingulate cortex in schizophrenia
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DOI：
10.1016/j.cortex.2012.02.001
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发表时间：
2013-03-01
期刊：
影响因子：
3.6
通讯作者：
Schloesser, Ralf G. M.
中科院分区：
文献类型：
--
作者：
Koch, Kathrin;Schultz, C. Christoph;Schloesser, Ralf G. M.
引言：精神分裂症患者的白色连接受损和灰质形态学改变已被反复报道。神经发育模型提出了灰质改变和白色物质缺陷之间的密切联系。然而，有没有研究调查皮质厚度的变化与白色物质连接changes.Methods：这结合扩散张量成像（DTI）表面为基础的形态学研究探讨了一个潜在的联系之间的中断在白色物质连接和皮质厚度的变化。使用FreeSurfer软件包（4.0.5版，http://surfer.nmr.harvard.edu）分析19例精神分裂症患者和20例健康对照者的大脑皮质厚度。
Introduction: Both impaired white matter connectivity and alterations in gray matter morphometry have repeatedly been reported in schizophrenia. Neurodevelopmental models propose a close linkage between gray matter alterations and white matter deficits. However, there are no studies investigating alterations in cortical thickness in relation to white matter connectivity changes.Methods: This combined diffusion tensor imaging (DTI) - surface based morphometry study examined a potential linkage between disruption in white matter connectivity and alterations in cortical thickness. Cortical thickness was analyzed using the FreeSurfer software package (version 4.0.5, http://surfer.nmr.harvard.edu)in a sample of 19 patients with schizophrenia and 20 healthy controls.Results: Whole brain node-by-node correlational analysis revealed a highly significant association (r = -.8, p