Chronic stress as a risk factor for Alzheimer's disease
Chronic stress as a risk factor for Alzheimer's disease
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DOI：
10.1515/revneuro-2014-0035
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发表时间：
2014-12-01
影响因子：
4.1
通讯作者：
Cano, Josefina
中科院分区：
文献类型：
--
作者：
Machado, Alberto;Herrera, Antonio J.;Cano, Josefina
本综述旨在指出，慢性压力能够加速阿尔茨海默病 (AD) 的出现，并提出前者是后者的危险因素。首先，在引言中，我们描述了一些人类流行病学研究，指出慢性压力可能会增加 AD 的发病率或出现率。之后，我们尝试用一些实验数据来证明这些流行病学结果的合理性。我们回顾了研究各种压力源对 AD 动物模型不同特征的影响的实验。此外，我们还指出了慢性压力对已知与 AD 相关的某些过程（例如炎症和葡萄糖代谢）影响的数据。随后，我们将一些已知与衰老和 AD 相关的过程联系起来，例如 β-淀粉样蛋白的积累、TAU 过度磷酸化、氧化应激和线粒体功能受损，强调它们如何受到慢性应激/糖皮质激素的影响，并与 AD 中对这些过程的描述进行比较。所有这些数据都支持这样的观点：慢性压力可以被视为 AD 的危险因素。
This review aims to point out that chronic stress is able to accelerate the appearance of Alzheimer's disease (AD), proposing the former as a risk factor for the latter. Firstly, in the introduction we describe some human epidemiological studies pointing out the possibility that chronic stress could increase the incidence, or the rate of appearance of AD. Afterwards, we try to justify these epidemiological results with some experimental data. We have reviewed the experiments studying the effect of various stressors on different features in AD animal models. Moreover, we also point out the data obtained on the effect of chronic stress on some processes that are known to be involved in AD, such as inflammation and glucose metabolism. Later, we relate some of the processes known to be involved in aging and AD, such as accumulation of beta-amyloid, TAU hyperphosphorylation, oxidative stress and impairement of mitochondrial function, emphasizing how they are affected by chronic stress/glucocorticoids and comparing with the description made for these processes in AD. All these data support the idea that chronic stress could be considered a risk factor for AD.