Associations of vitamin D binding protein variants with the vitamin D-induced increase in serum 25-hydroxyvitamin D
Associations of vitamin D binding protein variants with the vitamin D-induced increase in serum 25-hydroxyvitamin D
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DOI：
10.1016/j.clnesp.2018.12.005
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发表时间：
2019-02-01
影响因子：
3
通讯作者：
Avan, Amir
中科院分区：
文献类型：
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作者：
Mehramiz, Mehrane;Khayyatzadeh, Sayyed Saeid;Avan, Amir
背景资料：维生素D缺乏症是一个全球性问题，可以通过补充维生素D来改善;然而，个人对干预措施的反应各不相同。我们的目的是调查可能改变环境暴露对维生素D状态影响的遗传因素。我们调查的候选基因变异是Gc基因rs 4588多态性在维生素D受体（DBP）locus.Methods：共619健康的伊朗少女每周接受50000 IU的维生素D-3 9周。在基线和补充9周后测量血清25（OH）D浓度、代谢谱和膳食摄入量。结果：研究结果显示，DBP基因rs 4588多态性与血清25-羟基维生素D水平相关，在基线（p值= 0.03）和干预后（p值= 0.008）均与血清25-羟基维生素D水平相关。干预的结果似乎与基因有关，因此具有常见AA基因型的受试者对维生素D补充剂的反应更好（变化（%）AA携带者为427.1例，GG持有者为335.8例（530例），而不太常见的GG基因型携带者在9周后空腹血糖升高（变化（%）0（1.5））。我们的研究结果还表明，该变体和补充剂之间的统计学相互作用具有统计学显著性（干预效应p值
Background: Vitamin D deficiency is a global problem that may be improved by vitamin D supplementation; however, the individual's response to the intervention varies. We aimed to investigate possible genetic factors that may modify the impact of environmental exposure on vitamin D status. The candidate gene variant we investigated was the Gc gene-rs4588 polymorphism at the vitamin D receptor (DBP) locus.Methods: A total of 619 healthy adolescent Iranian girls received 50000 IU of vitamin D-3 weekly for 9 weeks. Serum 25(OH) D concentrations, metabolic profiles and dietary intake were measured at baseline and after 9 weeks of supplementation. The genotypes of the DBP variant (rs4588) were analyzed using the TaqMan genotyping assay.Results: Our results revealed that the rs4588 polymorphism might be associated with serum 25-hydroxy vitamin D both at baseline (p value = 0.03) and after intervention (p value = 0.008). It seemed that the outcome of the intervention was gene-related so that the subjects with common AA genotype were a better responder to vitamin D supplementation (Changes (%) 469.5 (427.1) in AA carriers vs. 335.8 (530) in GG holders), and carriers of the less common GG genotype experienced a rise in fasting blood glucose after 9 weeks (Changes (%) 0 (1.5)). Our findings also showed that the statistical interaction between this variant and supplementation was statistically significant (intervention effect p-value