γδ T cells enhance TSLP production and ILC2 accumulation in house dust mite-induced allergic airway inflammation
γδ T cells enhance TSLP production and ILC2 accumulation in house dust mite-induced allergic airway inflammation
复制标题
γδ T 细胞增强屋尘螨诱导的过敏性气道炎症中 TSLP 的产生和 ILC2 的积累
DOI：
10.1016/j.alit.2019.05.010
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发表时间：
2020
影响因子：
6.8
通讯作者：
Nakajima H.
中科院分区：
文献类型：
--
作者：
Saku A;Hirose K;Kageyama T;Kono K;Nakamura K;Yokota M;Maezawa Y;Suto A;Nakajima H.
哮喘是一种气道慢性过敏性炎症，其特征在于强烈的嗜酸性粒细胞和淋巴细胞浸润、粘液过度产生和气道对各种刺激的高反应性。1长期以来，过敏原特异性Th 2细胞一直被认为在肺中协调Th 2型免疫应答，并在特征的发展中发挥核心作用。然而，最近的证据表明，哮喘是一种异质性疾病，不仅由获得性免疫细胞介导，也由先天性免疫细胞介导。1先天性淋巴样细胞（ILC）是与哮喘相关的先天性细胞群之一，其特征是缺乏抗原特异性T细胞和B细胞受体，以及在细胞因子刺激下产生细胞因子的独特能力。在ILCs中，第2组ILCs（ILC 2）响应于上皮细胞来源的细胞因子而快速产生大量的Th 2细胞因子，包括IL-5、IL-13和IL-9，并且有助于哮喘的病理特征的发展。1除了ILC 2外，第3组ILCs（ILC 3）也参与了哮喘的某些表型的机制。2
Asthma is a chronic allergic inflammation in the airway which is characterized by intense eosinophilic and lymphocytic infiltration, mucus hyper-production, and airway hyper-responsiveness to a variety of stimuli. 1 Allergen-specific Th2 cells have long been thought to orchestrate Th2-type immune responses in the lung and play central roles in the development of the characteristics. However, recent evidence has demonstrated that asthma is a heterogeneous disease mediated by not only acquired but also innate immune cells. 1One of the innate cell populations shown to be involved in asthma is innate lymphoid cells (ILC), which are characterized by the lack of antigen-specific T cell and B cell receptors and its unique capability of cytokine production upon cytokine stimulation. Among ILCs, group 2 ILCs (ILC2) rapidly produce a large amount of Th2 cytokines, including IL-5, IL-13, and IL-9, in response to epithelial cell-derived cytokines, and contribute to the development of pathological features of asthma. 1 In addition to ILC2s, group 3 ILCs (ILC3s) are implicated in the mechanism of a certain phenotype of asthma. 2