Serum leptin concentrations and weight gain in postobese, postmenopausal women.
Serum leptin concentrations and weight gain in postobese, postmenopausal women.
复制标题
肥胖后、绝经后妇女的血清瘦素浓度和体重增加。
DOI：
10.1002/j.1550-8528.1998.tb00347.x
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Weinsier,RL
中科院分区：
文献类型：
--
作者：
Nagy,TR;Davies,SL;Hunter,GR;Darnell,B;Weinsier,RL
目的：本研究旨在确定低热量饮食减肥后血清瘦素浓度（根据脂肪量调整）是否能预测随后的体重增加。研究方法和程序：测定了14名中度肥胖、绝经后、有家族性肥胖易感性的非糖尿病妇女的体成分和血清瘦素浓度。在严格控制的代谢病房条件下，在肥胖状态前和平均体重减轻12.0 kg至正常体重后（肥胖状态后），对宏量营养素摄入和体重维持进行评估。四年后，在没有干预的情况下，重新评估体重和身体成分。结果：体重减轻导致脂肪量（29.7±5.4 vs. 20.3±4.7;kg）、体重指数（27.7±1.6 vs. 23.0±1.5;kg/m2）、体脂率（40.7±4.3 vs. 33.1±5.0）和血清瘦素浓度（31.8±16.0 vs. 11.5±5.4;ng/mL）显著降低。在肥胖和肥胖后状态下，血清瘦素浓度与脂肪量呈正相关（p<<0.05） （r= 0.67和r= 0.56）。然而，在肥胖和肥胖后状态下，剩余血清瘦素浓度（根据脂肪量调整）与随访期间体重（p<= 0.61和0.52）、脂肪量（p= 0.72和0.42）、体重指数（p= 0.59和0.33）或体脂率（p= 0.84和0.46）的变化无关。讨论：这些发现不支持相对低浓度瘦素预测减肥后体重反弹的假设。然而，由于本研究的受试者数量有限，需要进一步的研究。
Objective: This study was designed to determine if serum leptin concentrations (adjusted for fat mass) after weight loss on a low‐calorie diet predict subsequent weight gain.Research Methods and Procedures: Body composition and serum leptin concentrations were determined on 14 moderately obese, postmenopausal, nondiabetic women with a familial predisposition to obesity. Assessments were obtained under tightly controlled metabolic ward conditions of macronutrient intake and weight maintenance both before (obese state) and after a mean weight loss of 12.0 kg to normal body weight (postobese state). Four years later, without intervention, body weight and body composition were reassessed.Results: Weight loss resulted in significant decreases in fat mass (29.7 ± 5.4 vs. 20.3 ± 4.7; kg), body mass index (27.7 ± 1.6 vs. 23.0 ± 1.5; kg/m2), percent body fat (40.7 ± 4.3 vs. 33.1 ± 5.0), and serum leptin concentrations (31.8 ± 16.0 vs. 11.5 ± 5.4; ng/mL). Serum leptin concentrations were positively correlated (p<<0.05) with fat mass in both the obese and postobese states (r= 0.67 andr= 0.56, respectively). However, residual serum leptin concentrations (adjusted for fat mass) in the obese and postobese states were not related to changes in body weight (p<= 0.61 and 0.52), fat mass(p= 0.72 and 0.42), body mass index (p= 0.59 and 0.33), or percent body fat(p= 0.84 and 0.46) over the follow‐up period.Discussion: These finding do not support the hypothesis that relatively low concentrations of leptin predict weight regain after weight loss. However, because the number of subjects in this study was limited, further studies are warranted.