rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery.
rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery.
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DOI：
10.1007/s11695-015-1872-7
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发表时间：
2015-11
期刊：
影响因子：
2.9
通讯作者：
Greenland P
中科院分区：
文献类型：
--
作者：
Rasmussen-Torvik LJ;Baldridge AS;Pacheco JA;Aufox SA;Kim KY;Silverstein JC;Denham EW;Hungness E;Smith ME;Greenland P
我们研究了34个单核苷酸多态性与Roux-en-Y手术后9.5年体重减轻的关系。参与者是NUgene生物库中的注册者，存储了DNA和相关的电子健康记录。95名自我认定的白色参与者接受了手术，并在术后1年至9.5年之间获得了随访体重。在长期体重减轻的重复线性混合模型（p = .004）中，SNP rs 4771122是与手术后长期体重减轻最显著相关的变体。在这个模型中，每增加一个次要等位基因的拷贝，体重减轻的百分比就会增加近5%。同样的SNP也与体重减轻轨迹、体重减轻最低点和手术后2年的体重减轻名义上显著相关（p <0.05）。
We examined the association of 34 single nucleotide polymorphisms with weight loss up to 9.5 years after Roux-en-Y surgery. Participants were enrollees in the NUgene biobank with stored DNA and linked electronic health records. Ninety-five self-identified white participants underwent surgery and had follow-up weights obtained between 1 and 9.5 years after surgery. SNP rs4771122 was the variant most significantly associated with long term weight loss after surgery in a repeated linear mixed model (p = .004) of long-term weight loss. In this model, each additional copy of the minor allele was associated with nearly 5 percent greater percentage weight loss. This same SNP was also nominally significantly (p < .05) associated with weight loss trajectories, weight loss nadir, and weight loss 2 years after surgery.