REDUCED BRAIN METABOLISM IN HYPERACTIVE GIRLS
REDUCED BRAIN METABOLISM IN HYPERACTIVE GIRLS
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DOI：
10.1097/00004583-199407000-00012
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发表时间：
1994-07-01
影响因子：
13.3
通讯作者：
ZAMETKIN, AJ
中科院分区：
文献类型：
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作者：
ERNST, M;LIEBENAUER, LL;ZAMETKIN, AJ
目的：本研究采用正电子发射断层扫描和F-18-氟脱氧葡萄糖评估注意缺陷多动障碍（ADHD）和性别对脑葡萄糖代谢（CMRglu）的影响。方法：19名正常（6名女性; 14.3 +/- 1.3岁）和20名ADHD青少年（5名女性; 14.7 +/- 1.6岁）参加了这项研究。在30分钟的F-18-氟脱氧葡萄糖摄取期间使用听觉连续性能任务。结果：ADHD组（N = 20）和正常组（N = 19）的CMRglu总体或区域差异无统计学意义。然而，ADHD女孩（N = 5）的总体CMRglu比正常女孩（N = 6）低15.0%（p = 0.04），而ADHD男孩的总体CMRglu与正常男孩没有什么不同。此外，ADHD女孩的总体CMRglu比ADHD男孩低19.6%（p = 0.02），正常女孩和正常男孩之间没有差异。临床评定量表不能区分ADHD女孩和ADHD男孩，也不能区分正常女孩和正常男孩。结论：女性比男性更大的大脑代谢异常强烈强调，应更多地关注ADHD女孩的研究。
Objective: This study assesses the effect of attention-deficit hyperactivity disorder (ADHD) and gender on cerebral glucose metabolism (CMRglu), using positron emission tomography and F-18-fluorodeoxyglucose. Method: Nineteen normal (6 females; 14.3 +/- 1.3 years old) and 20 ADHD adolescents (5 females; 14.7 +/- 1.6 years old) participated in the study. An auditory continuous performance task was used during the 30-minute uptake of F-18-fluorodeoxyglucose. Results: There were no statistically significant differences in global or regional CMRglu between ADHD (N = 20) and normal (N = 19) adolescents. However, the global CMRglu in ADHD girls (N = 5) was 15.0% lower than in normal girls (N = 6) (p = .04), while global CMRglu in ADHD boys was not different than in normal boys. Furthermore, global CMRglu in ADHD girls was 19.6% lower than in ADHD boys (p = .02) and was not different between normal girls and normal boys. Clinical rating scales did not differentiate ADHD girls from ADHD boys, nor normal girls from normal boys. Conclusions: The greater brain metabolism abnormalities in females than males strongly stress that more attention be given to the study of girls with ADHD.