SERA -- An advanced treatment planning system for neutron therapy and BNCT
SERA -- An advanced treatment planning system for neutron therapy and BNCT
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SERA——用于中子治疗和 BNCT 的先进治疗计划系统
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
M. Rossmeier
中科院分区：
文献类型：
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作者：
D. Nigg;C. Wemple;D. E. Wessol;F. Wheeler;C. Albright;M. T. Cohen;Michael W. Frandsen;G. J. Harkin;M. Rossmeier
硼中子俘获治疗（BNCT）需要在患者特定的基础上进行详细的治疗计划计算。在过去的几年里，两个专门为BNCT开发的综合治疗计划系统已在美国临床使用。MacNCT的BNCT治疗计划系统用于马萨诸塞州理工学院正在进行的BNCT临床试验。由爱达荷州国家工程与环境实验室（INEEL）与蒙大拿州立大学（MSU）合作独立开发的第二个系统BNCT rtpe（BNCT放射治疗规划环境）用于在布鲁克海文国家实验室（BNL）针对胶质母细胞瘤的当前系列BNCT临床试验中的治疗规划。后一种系统也被许可在世界各地的其他几个BNCT研究机构使用。尽管当前可用的BNCT规划系统已经很好地服务于它们的目的，但是它们相对于标准光子治疗规划软件遭受稍微长的计算时间（每个场2至3 CPU小时或更多）。这在很大程度上是由于需要明确的三维解决方案的相关传输方程。适用于光子输运计算的简化近似一般不适用于中子输运计算。因此，BNCT治疗计划的更高计算速度必须通过应用改进的数值技术而不是通过简化控制方程来实现。INEEL和MSU最近的努力一直致力于实现这一目标。这导致了这种类型的计算和随后创建的新的模拟环境的放射治疗应用（SERA）治疗计划系统的BNCT的新的范例。SERA目前正处于与BNL试验相关的初步临床试验中，预计在1999年期间全面发布后将取代目前的BNCT rtpe系统。«少
Detailed treatment planning calculations on a patient-specific basis are required for boron neutron capture therapy (BNCT). Two integrated treatment planning systems developed specifically for BNCT have been in clinical use in the United States over the past few years. The MacNCTPLAN BNCT treatment planning system is used in the clinical BNCT trials that are underway at the Massachusetts Institute of Technology. A second system, BNCT{_}rtpe (BNCT radiation therapy planning environment), developed independently by the Idaho national Engineering and Environmental Laboratory (INEEL) in collaboration with Montana State University (MSU), is used for treatment planning in the current series of BNCT clinical trials for glioblastoma at Brookhaven National Laboratory (BNL). This latter system is also licensed for use at several other BNCT research facilities worldwide. Although the currently available BNCT planning systems have served their purpose well, they suffer from somewhat long computation times (2 to 3 CPU-hours or more per field) relative to standard photon therapy planning software. This is largely due to the need for explicit three-dimensional solutions to the relevant transport equations. The simplifying approximations that work well for photon transport computations are not generally applicable to neutron transport computations. Greater computational speeds for BNCT treatment planning must thereforemore » generally be achieved through the application of improved numerical techniques rather than by simplification of the governing equations. Recent efforts at INEEL and MSU have been directed toward this goal. This has resulted in a new paradigm for this type of calculation and the subsequent creation of the new simulation environment for radiotherapy applications (SERA) treatment planning system for BNCT. SERA is currently in initial clinical testing in connection with the trials at BNL, and it is expected to replace the present BNCT{_}rtpe system upon general release during 1999.« less