Twenty five year mortality and air pollution: results from the French PAARC survey
Twenty five year mortality and air pollution: results from the French PAARC survey
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DOI：
10.1136/oem.2004.014746
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发表时间：
2005-07-01
影响因子：
4.9
通讯作者：
Baldi, I
中科院分区：
文献类型：
--
作者：
Filleul, L;Rondeau, V;Baldi, I
目的和方法：对 1974 年参加 PAARC 调查（空气污染和慢性呼吸道疾病）时居住在法国七个城市 24 个地区的 14 284 名成年人进行了空气污染对死亡率的长期影响的研究。在三年内（1974-76 年）对 24 个地区进行了二氧化硫、总悬浮颗粒物、黑烟、二氧化氮和一氧化氮的每日测量。应用控制个体混杂因素（吸烟、教育水平、体重指数、职业暴露）的 Cox 比例风险模型，并使用脆弱模型来考虑空间相关性。空气污染指标为平均浓度。结果：模型在排除受当地交通影响的六个区域监测器（NO/NO2 > 3，以 ppb 为单位）之前和之后运行。排除这些区域后，分析显示，10 个月中，TSP、BS、NO2 和 NO 的非意外死亡的调整后风险比 (95% CI) 分别为 1.05（1.02 至 1.08）、1.07（1.03 至 1.10）、1.14（1.03 至 1.25）和 1.11（1.05 至 1.17）。分别为毫克/米(3)。观察到肺癌和心肺原因的一致模式。结论：25 世纪 70 年代评估的城市空气污染与法国 25 年来死亡率增加有关。
Aims and Methods: Long term effects of air pollution on mortality were studied in 14 284 adults who resided in 24 areas from seven French cities when enrolled in the PAARC survey (air pollution and chronic respiratory diseases) in 1974. Daily measurements of sulphur dioxide, total suspended particles, black smoke, nitrogen dioxide, and nitric oxide were made in 24 areas for three years (1974-76). Cox proportional hazards models controlling for individual confounders (smoking, educational level, body mass index, occupational exposure) were applied, and frailty models used to take into account spatial correlation. Indicators of air pollution were the mean concentration.Results: Models were run before and after exclusion of six area monitors influenced by local traffic (NO/NO2 > 3 in ppb). After exclusion of these areas, analyses showed that adjusted risk ratios (95% CI) for TSP, BS, NO2, and NO for non-accidental mortality were 1.05 (1.02 to 1.08), 1.07 (1.03 to 1.10), 1.14 (1.03 to 1.25), and 1.11 (1.05 to 1.17) for 10 mg/m(3) respectively. Consistent patterns for lung cancer and cardiopulmonary causes were observed.Conclusions: Urban air pollution assessed in the 1970s was associated with increased mortality over 25 years in France.