FOXM1 and its oncogenic signaling in pancreatic cancer pathogenesis.
FOXM1 and its oncogenic signaling in pancreatic cancer pathogenesis.
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DOI：
10.1016/j.bbcan.2014.01.002
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发表时间：
2014-04
影响因子：
11.2
通讯作者：
Xie, Keping
中科院分区：
文献类型：
--
作者：
Huang, Chen;Du, Jiawei;Xie, Keping
胰腺癌是一种毁灭性的疾病，总体5年生存率不到5%。多种信号通路参与了胰腺癌的发生，如Wnt/β-catenin、Notch、Hedgehog、缺氧诱导因子、信号转导和转录激活因子、特异性蛋白/Krüppel样因子和Forkhead box(FOX)等。近年来，越来越多的证据表明转录因子FOXM1在包括胰腺癌在内的多种人类肿瘤的发生、发展和转移中起重要作用。本文就目前胰腺癌分子发病机制的研究进展作一综述，重点介绍FOXM1的功能和调控，以及FOXM1作为新的分子靶点防治胰腺癌的理论基础。
Pancreatic cancer is a devastating disease with an overall 5-year survival rate less than 5%. Multiple signaling pathways are implicated in the pathogenesis of pancreatic cancer, such as Wnt/β-catenin, Notch, Hedgehog, hypoxia-inducible factor, signal transducer and activator of transcription, specificity proteins/Krüppel-like factors, and Forkhead box (FOX). Recently, increasing evidence has demonstrated that the transcription factor FOXM1 plays important roles in the initiation, progression, and metastasis of a variety of human tumors, including pancreatic cancer. In this review, we focus on the current understanding of the molecular pathogenesis of pancreatic cancer with a special focus on the function and regulation of FOXM1 and rationale for FOXM1 as a novel molecular target for pancreatic cancer prevention and treatment.
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影响因子：
3.9
作者：
Bellelli R;Castellone MD;Garcia-Rostan G;Ugolini C;Nucera C;Sadow PM;Nappi TC;Salerno P;Cantisani MC;Basolo F;Gago TA;Salvatore G;Santoro M
通讯作者：
Santoro M
前列腺癌的基因表达谱揭示了多个分子途径在转移过程中的参与。
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3.8
作者：
Chandran, Uma R.;Ma, Changqing;Dhir, Rajiv;Bisceglia, Michelle;Lyons-Weiler, Maureen;Liang, Wenjing;Michalopoulos, George;Becich, Michael;Monzon, Federico A.
通讯作者：
Monzon, Federico A.
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4
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通讯作者：
Sarkar, Fazlul H.
影响因子：
64.8
作者：
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通讯作者：
Serrano, L
影响因子：
3.8
作者：
Ahmad, Aamir;Wang, Zhiwei;Sarkar, Fazlul H.
通讯作者：
Sarkar, Fazlul H.