CHLORHEXIDINE DIGLUCONATE - AN AGENT FOR CHEMICAL PLAQUE CONTROL AND PREVENTION OF GINGIVAL INFLAMMATION
CHLORHEXIDINE DIGLUCONATE - AN AGENT FOR CHEMICAL PLAQUE CONTROL AND PREVENTION OF GINGIVAL INFLAMMATION
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DOI：
10.1111/j.1600-0765.1986.tb01517.x
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发表时间：
1986-01-01
影响因子：
3.5
通讯作者：
BRECX, MC
中科院分区：
文献类型：
--
作者：
LANG, NP;BRECX, MC
在选择预防和治疗牙周病的抗菌药物时，应考虑以下因素：1。特异性，2。功效，3。实质性，4。安全5稳定使用这些标准，近年来已经评价了几种抗生素和防腐剂用于化学菌斑控制。虽然抗生素主要用于特定菌斑假设，但防腐剂更适合于非特异性菌斑概念。几种防腐剂会阻碍牙菌斑的形成，甚至破坏旧牙菌斑。例如，季铵化合物、金属离子与嘧啶或与氟化物的组合、酚类化合物和植物生物碱已经产生20-20%的牙菌斑减少效果，并且还略微延迟牙龈炎的发展。多年的文献研究已经证实，二葡萄糖酸氯己定是安全、稳定的，并且由于其巨大的直接性，可有效预防和控制牙菌斑形成、破碎现有牙菌斑以及抑制和减少牙龈炎的发展。在为期6个月或更长时间的研究中，与安慰剂对照相比，洗必泰已被证明可减少牙龈炎50-50%。洗必泰是最有效和最彻底的测试抗牙菌斑和抗牙龈炎剂今天已知的。
In selecting antimicrobial agents for the prevention and treatment of periodontal diseases, the following factors should be considered: 1. Specificity, 2. Efficacy, 3. Substantivity, 4. Safety, 5. Stability. Using these criteria, several antibiotics and antiseptics have been evaluated in recent years for chemical plaque control. While antibiotics are mostly used under a specific plaque hypothesis, antiseptics are more suitable for a non‐specific plaque concept. Several antiseptics hinder plaque formation or even break up old plaque. For example, quaternary ammonium compounds, combinations of metal ions with pyrimidines or with fluorides, phenolic compounds, and plant alkaloids have yielded a plaque reducing effect of 20–20% and have also delayed slightly the development of gingivitis. Years of documented research have established that chlorhexidine digluconate is safe, stable, and, owing to its great substantivity, effective in preventing and controlling plaque formation, breaking up existing plaque, and inhibiting and reducing the development of gingivitis. In studies of 6 months and longer, chlorhexidine has been shown to reduce gingivitis by 50–50% compared to a placebo control. Chlorhexidine is the most effective and most thoroughly tested antiplaque and antigingivitis agent known today.