Isolation and Photoinduced Conversion of 6-epi-Stephacidins from Aspergillus taichungensis
Isolation and Photoinduced Conversion of 6-epi-Stephacidins from Aspergillus taichungensis
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台中曲霉 6-epi-Stephacidins 的分离和光诱导转化
DOI：
10.1021/ol400694h
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发表时间：
2013-05-03
期刊：
影响因子：
5.2
通讯作者：
Li, Dehai
中科院分区：
文献类型：
--
作者：
Cai, Shengxin;Luan, Yepeng;Li, Dehai
从台中曲霉（Aspergillusttaichungensis）中分离得到三个异戊烯化吲哚生物碱，其核心环为罕见的反双环[2.2.2]二氮杂辛烷环（5-7）。通过核磁共振、X射线衍射和圆二色谱等方法确定了化合物的结构和绝对构型。含有螺环中心的（+）-Versicolamides B和C（8-9）以及7个类似物（7，10-15）作为6的光诱导转化产物被分离。生物学评价表明，6和7显示出显著的细胞毒性，IC 50值在低微摩尔范围内。
Three prenylated indole alkaloids with a rare anti bicyclo-[2.2.2]diazaoctane core ring (5-7) were isolated from Aspergillus taichungensis. The structures including absolute configurations were elucidated based on NMR, X-ray, and CD methods. (+)-Versicolamides B and C (8-9) which contain a spiro-center, together with seven analogues (7, 10-15), were isolated as photoinduced conversion products of 6. Biological evaluation indicated that 6 and 7 exhibited significant cytotoxicities with IC50 values in the low micromolar range.