Vitreous humor analysis for the detection of xenobiotics in forensic toxicology: a review.
Vitreous humor analysis for the detection of xenobiotics in forensic toxicology: a review.
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DOI：
10.1007/s11419-015-0294-5
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发表时间：
2016
影响因子：
2.2
通讯作者：
Guitton J
中科院分区：
文献类型：
--
作者：
Bévalot F;Cartiser N;Bottinelli C;Fanton L;Guitton J
玻璃体液（vitamenthumor，VH）是一种凝胶状物质，存在于眼后房，在眼球中起机械作用。它一直是许多研究的主题，在各种法医应用，主要是评估死后的时间和死后的化学分析。由于大多数存在于血流中的外源性物质在穿过选择性血液-视网膜屏障后在VH中被检测到，VH是用于法医毒理学的替代基质。相对于其他生物基质，VH分析提供了特别的优势：它不太容易发生死后再分布，易于收集，对分析过程具有相对较少的干扰化合物，并且在死亡后随时间推移显示样品稳定性。本研究是VH生理学、药物转运和消除的概述。收集，储存，分析技术和解释的结果，从定性和定量的观点进行了处理。因此，讨论了外源性物质在VH样品中的分布，并通过报告来自300多份病例报告的106种药物浓度的表格进行了说明。为此，对MEDLINE数据库中1969年至2015年4月30日的出版物进行了调查。
Vitreous humor (VH) is a gelatinous substance contained in the posterior chamber of the eye, playing a mechanical role in the eyeball. It has been the subject of numerous studies in various forensic applications, primarily for the assessment of postmortem interval and for postmortem chemical analysis. Since most of the xenobiotics present in the bloodstream are detected in VH after crossing the selective blood-retinal barrier, VH is an alternative matrix useful for forensic toxicology. VH analysis offers particular advantages over other biological matrices: it is less prone to postmortem redistribution, is easy to collect, has relatively few interfering compounds for the analytical process, and shows sample stability over time after death. The present study is an overview of VH physiology, drug transport and elimination. Collection, storage, analytical techniques and interpretation of results from qualitative and quantitative points of view are dealt with. The distribution of xenobiotics in VH samples is thus discussed and illustrated by a table reporting the concentrations of 106 drugs from more than 300 case reports. For this purpose, a survey was conducted of publications found in the MEDLINE database from 1969 through April 30, 2015.