FTO gene variation and measures of body mass in an African population.
FTO gene variation and measures of body mass in an African population.
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DOI：
10.1186/1471-2350-10-21
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发表时间：
2009-03-05
影响因子：
--
通讯作者：
Prentice AM
中科院分区：
文献类型：
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作者：
Hennig BJ;Fulford AJ;Sirugo G;Rayco-Solon P;Hattersley AT;Frayling TM;Prentice AM
在欧洲白色人群中，脂肪量和肥胖相关（FTO）基因的变异与体重指数（BMI）和肥胖可重复地相关。来自亚洲人和非洲裔美国人的数据则不那么具有决定性。我们评估了16 FTO多态性对体重的影响，在一个大的人口主要是瘦冈比亚（Nmax 2208）参与长期监测计划，提供当代和早期生活的人体测量。在此筛选的16个FTO tagSNPs，包括与欧洲人BMI相关的几个，与出生体重（BWT）、1-2奥尔兹早期体重增加、成人BMI（≥ 18岁）或所有年龄段的身高体重（WFH）z评分无关。基因型与WFH z评分或其他体重指标之间没有相关性。置信限表明，对于任何SNP（不包括等位基因< 15%的三个SNP），WFH z分数的效应大小从未超过0.17单位/等位基因拷贝。等位基因频率最低rs 9939609效应量的置信区间与先前在欧洲报告的置信区间不重叠。据我们所知，这是第一次研究FTO基因变异在一个良好的特征非洲人口。我们的研究结果表明，FTO基因变异不影响冈比亚人的体重测量生活在传统的生活方式，或有一个比欧洲人检测到的影响较小。由于研究设计和分析的差异，这些发现与以前在非洲裔美国人中进行的研究结果没有直接可比性。与食物供应充足的类似种族人群相比，FTO基因型对体重的任何影响在几乎没有多余食物的瘦人群中的相关性也可能有限。
Variation in the fat mass and obesity associated (FTO) gene has been reproducibly associated with body mass index (BMI) and obesity in populations of White European origin. Data from Asians and African-Americans is less conclusive. We assessed the effect of 16 FTO polymorphisms on body mass in a large population of predominantly lean Gambians (Nmax 2208) participating in a long-term surveillance program providing contemporary and early-life anthropometric measurements. Sixteen FTO tagSNPs screened here, including several associated with BMI in Europeans, were not associated with birth weight (BWT), early weight gain in 1–2 year olds, BMI in adults (≥ 18 y), or weight-for-height (WFH) z-score across all ages. No association was seen between genotype and WFH z-score or other measures of body mass. The confidence limits indicate that the effect size for WFH z-score never exceeded 0.17 units per allele copy for any SNP (excluding the three SNPs with allele < 15%). with much the lowest allele frequency. The confidence interval of the effect size for rs9939609 did not overlap that reported previously in Europeans. To our knowledge this is the first study of FTO gene variation in a well-characterised African population. Our results suggest that FTO gene variation does not influence measures of body mass in Gambians living a traditional lifestyle, or has a smaller effect than that detected in Europeans. These findings are not directly comparable to results from previous studies in African-Americans due to differences in study design and analysis. It is also possible that any effect of FTO genotype on body mass is of limited relevance in a lean population where little excess food is available, compared to similar ethnic populations where food supply is plentiful.