Prediagnosis Food Patterns Are Associated with Length of Survival from Epithelial Ovarian Cancer
Prediagnosis Food Patterns Are Associated with Length of Survival from Epithelial Ovarian Cancer
复制标题
DOI：
10.1016/j.jada.2009.11.014
复制
发表时间：
2010-03-01
影响因子：
--
通讯作者：
Davis, Faith G.
中科院分区：
文献类型：
--
作者：
Dolecek, Therese A.;McCarthy, Bridget J.;Davis, Faith G.
背景饮食因素一直是卵巢癌病因学研究的焦点，并可能影响生存率。的确，最近在美国以外的三项研究表明，饮食在卵巢癌生存中起作用。目的本研究的目的是评估诊断为卵巢癌的妇女，其报告的诊断前饮食模式更接近反映最佳健康建议的假设，与报告较差饮食的妇女相比，生存优势。采用向上研究设计，在1994-1998年诊断为上皮性卵巢癌的341名伊利诺斯州库克县居民中，检查诊断前日常饮食对生存率的影响。这些妇女参加了以前的病例对照研究，其中饮食使用经验证的食物频率问卷进行评估。这些饮食信息是利用2005年美国人饮食指南进行分类的。通过2005年的死亡，确定使用国家死亡指数search.Statistical分析调整重要的协变量的风险比（HR）和95%置信区间（CI）从比例风险回归模型，以评估饮食对卵巢癌生存的影响。更长的生存期与总水果和蔬菜（HR 0.61，95% CI 0.38至0.98，趋势P =0.10）和单独蔬菜（HR 0.66，95% CI 0.43至1.01，趋势P = 0.10）相关
Background Dietary factors have been the focus of many studies on the etiology of ovarian cancer and may potentially affect survival. Indeed, three recent studies outside the United States have suggested that diet plays a role in ovarian cancer survival.Objective The study purpose was to evaluate the hypothesis that women diagnosed with ovarian cancer whose reported prediagnosis food patterns more closely reflect recommendations for optimal health experience a survival advantage compared with those reporting poorer diets.Design A longitudinal follow-up study design was used to examine prediagnosis usual diet effects on survival among 341 Cook County, Illinois, residents diagnosed with epithelial ovarian cancer during 1994-1998. These women participated in a previous case-control study where diet was assessed using a validated food frequency questionnaire. This diet information was categorized utilizing the Dietary Guidelines for Americans 2005. Deaths through 2005 were ascertained using a national death index search.Statistical analysis Hazard ratios (HR) and 95% confidence intervals (CI) adjusting for important covariables were obtained from proportional hazards regression models to evaluate diet effects on survival from ovarian cancer.Results Comparisons of high to low food group or subgroup intakes demonstrated statistically significant prediagnosis food pattern associations with survival time. Longer survival was associated with total fruits and vegetables (HR 0.61, 95% CI 0.38 to 0.98, P for trend=0.10) and vegetables separately (HR 0.66, 95% CI 0.43 to 1.01, P for trend