Tissue Quantification With Acoustic Radiation Force Impulse Imaging: Measurement Repeatability and Normal Values in the Healthy Liver
Tissue Quantification With Acoustic Radiation Force Impulse Imaging: Measurement Repeatability and Normal Values in the Healthy Liver
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DOI：
10.2214/ajr.09.3923
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发表时间：
2010-07-01
影响因子：
5
通讯作者：
Mucelli, Roberto Pozzi
中科院分区：
文献类型：
--
作者：
D'Onofrio, Mirko;Gallotti, Anna;Mucelli, Roberto Pozzi
OBJECTIVE.本研究的目的是描述声辐射力脉冲技术的最可靠的测量程序，并定义正常的波速度值在一个健康的liver.SubJECTS和方法。20名健康志愿者接受了声辐射力脉冲成像组织定量，并入选本前瞻性研究。所有患者均由两名独立操作者同时进行检查。每例受试者获得24个测量值。进行了术中和术中评价。采用Student t检验对所有平均数据进行统计学比较。p < 0.05的值被认为是显著的。进行比较分析，并计算组间相关系数。操作员获得了960个测量值。由一名操作员在肝右叶深处获得的平均剪切波速度值与在右叶表面获得的值之间（1.56 vs 1.90 m/s）以及在右叶深处获得的平均值与在左叶深处获得的平均值之间（1.56 vs 1.84 m/s）存在统计学显著差异。另一名操作员也得到了类似的结果。两名操作员在肝右叶深处获得的所有平均值的分布（95% CI，1.391-1.725）比在表面获得的分布（95% CI，1.664-2.136）分散更小。在77.5%的情况下，剪切波速度在1和2 m/s之间。两名术者对肝右叶进行的比较无统计学显著差异。右叶深部测量的组间相关系数为0.87（p < 0.0001）。当应用于肝右叶的较深部分时，肝组织的声辐射力脉冲成像量化更可再现。
OBJECTIVE. The purpose of this study was to describe the most reliable measurement procedure for acoustic radiation force impulse technology and to define the normal wave velocity values in a healthy liver.SUBJECTS AND METHODS. Twenty healthy volunteers underwent acoustic radiation force impulse imaging tissue quantification and were enrolled in this prospective study. All patients were examined by two independent operators at the same time. Twenty-four measurements per subject were obtained. Intraoperator and interoperator evaluations were performed. Statistical comparison of all mean data was performed with Student's t test. A value of p < 0.05 was considered significant. A comparative analysis was performed, and interclass correlation coefficients were calculated.RESULTS. The operators obtained 960 measurements. A statistically significant difference was found between the mean shear wave velocity values obtained by one operator deep in the right lobe of the liver and the values obtained on the surface of the right lobe (1.56 vs 1.90 m/s) and between the mean values obtained deep in the right lobe and those obtained deep in the left lobe (1.56 vs 1.84 m/s). The other operator had similar results. The distribution of all mean values obtained by both operators deep in the right hepatic lobe exhibited less dispersion (95% CI, 1.391-1.725) than those obtained on the surface (95% CI, 1.664-2.136). In 77.5% of cases, the shear wave speeds were between 1 and 2 m/s. No statistically significant difference was found in the comparisons performed on the right hepatic lobe by the two operators. The interclass correlation coefficient calculated for measurements deep in the right lobe was 0.87 (p < 0.0001).CONCLUSION. Acoustic radiation force impulse imaging quantification of hepatic tissue is more reproducible when applied to the deeper portion of the right lobe of the liver.