Extracellular matrix proteins and tumor angiogenesis.
Extracellular matrix proteins and tumor angiogenesis.
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DOI：
10.1155/2010/586905
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发表时间：
2010
影响因子：
--
通讯作者：
Petrik J
中科院分区：
文献类型：
--
作者：
Campbell NE;Kellenberger L;Greenaway J;Moorehead RA;Linnerth-Petrik NM;Petrik J
肿瘤发展是一个复杂的过程，依赖于许多细胞区室之间的相互作用和通信。实体瘤的大部分肿块由富含细胞外基质的基质组成。在该基质内是基质细胞蛋白质的宿主，其调节调节肿瘤发生过程的无数蛋白质的表达和功能。对肿瘤生长和进展至关重要的过程之一是血管生成，或从预先存在的脉管系统形成新血管。 在细胞外基质内是结构蛋白、蛋白酶宿主以及以严格调节的方式控制肿瘤血管生成的常驻促血管生成因子和抗血管生成因子。本文就细胞外基质和ECM蛋白在肿瘤血管生成调控中的作用作一综述。
Tumor development is a complex process that relies on interaction and communication between a number of cellular compartments. Much of the mass of a solid tumor is comprised of the stroma which is richly invested with extracellular matrix. Within this matrix are a host of matricellular proteins that regulate the expression and function of a myriad of proteins that regulate tumorigenic processes. One of the processes that is vital to tumor growth and progression is angiogenesis, or the formation of new blood vessels from preexisting vasculature. Within the extracellular matrix are structural proteins, a host of proteases, and resident pro- and antiangiogenic factors that control tumor angiogenesis in a tightly regulated fashion. This paper discusses the role that the extracellular matrix and ECM proteins play in the regulation of tumor angiogenesis.