A new gene on C. elegans chromosome V.
A new gene on C. elegans chromosome V.
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DOI：
10.17912/micropub.biology.000496
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发表时间：
2021
影响因子：
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通讯作者：
Norris A
中科院分区：
文献类型：
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作者：
Iyengar A;Diamantakis S;Norris A
线虫是第一个完成基因组测序的动物。在此后的几十年里，基因组继续得到积极的管理、注释和改进。在这里，我们报告了在基因组的一个区域中发现的一个新基因，该基因目前与任何已注释的基因或特征都没有关联。我们提出了RNA-seq和RT-PCR证据，证明该基因在可检测的水平上表达，并且它是选择性剪接的。新基因(Y97E10C.2)与两个上游基因共享一个操纵子。我们提供了上游基因T05B11.7缺失外显子的RNA-seq和RT-PCR证据，以及选择性剪接的外显子。
C. elegans was the first animal to have its genome completely sequenced. In the decades since, the genome continues to be actively curated, annotated, and improved. Here we report the discovery of a new gene in a region of the genome that is currently not associated with any annotated gene or feature. We present RNA-seq and RT-PCR evidence that this gene is expressed at detectable levels, and that it is alternatively spliced. The new gene (Y97E10C.2) shares an operon with two upstream genes. We provide RNA-seq and RT-PCR evidence for a missing exon in the upstream gene T05B11.7, as well as an alternatively-spliced exon.