Elevated Plasma Pentraxin 3 Levels Are Associated With Development and Progression of Diabetic Retinopathy in Korean Patients With Type 2 Diabetes Mellitus
Elevated Plasma Pentraxin 3 Levels Are Associated With Development and Progression of Diabetic Retinopathy in Korean Patients With Type 2 Diabetes Mellitus
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DOI：
10.1167/iovs.14-14864
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发表时间：
2014-09-01
影响因子：
4.4
通讯作者：
Woo, Je Moon
中科院分区：
文献类型：
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作者：
Yang, Hyun Seung;Woo, Jong Eun;Woo, Je Moon
目的。评估血浆戊曲霉素3 （PTX3）水平升高与糖尿病视网膜病变（DR）的发生和/或进展之间的关系。本病例对照研究共纳入92例合并DR的糖尿病患者（3组）、30例未合并DR的糖尿病患者（2组）和41例正常受试者（1组）。我们测量了血浆PTX3和高敏c反应蛋白（hsCRP）浓度的对数转化值，并将其用于我们的分析。亚组分析将3组分为轻度、中度、重度非增生性和增生性4个亚组。在我们的163名参与者中，1、2和3组的平均血浆PTX3水平分别为916.1 +/- 532.2、1093.7 +/- 1034.2和1817.9 +/- 1776.9 pg/mL。三组患者糖尿病病程（DM）、糖化血红蛋白病程（HbA1c）、hsCRP、PTX3病程（log hsCRP、log PTX3）差异均有统计学意义（P = 0.008、P < 0.001、P = 0.046、P < 0.001）。在亚组分析中，血浆log PTX3水平升高与DR严重程度相关（R = 0.372, P < 0.001）。多因素logistic分析显示，DR的发生与DM持续时间和log PTX3值的相关性显著（分别为P = 0.014和P = 0.025），而与log hsCRP值的相关性在单因素分析中不显著（P = 0.129）。采用对数PTX3和对数hsCRP值绘制DR发展的受试者工作特征曲线，曲线下面积分别为0.721 （P = 0.001）和0.614 （P = 0.087）。血浆PTX3与DR的发生和进展呈正相关，可能比hsCRP更准确地预测DR的发生。
PURPOSE. To evaluate the association between elevated levels of plasma pentraxin 3 (PTX3) and the development and/or progression of diabetic retinopathy (DR).METHODS. In this case-control study, 92 diabetic patients with DR (group 3), 30 diabetic patients without DR (group 2), and 41 normal subjects (group 1) were enrolled. Log transformed values of plasma PTX3 and high-sensitivity C-reactive protein (hsCRP) concentrations were measured and used in our analysis. For subgroup analysis, group 3 was divided into four subgroups: mild, moderate, severe nonproliferative, and proliferative DR.RESULTS. In our 163 participants, average plasma PTX3 levels were 916.1 +/- 532.2, 1093.7 +/- 1034.2, and 1817.9 +/- 1776.9 pg/mL for groups 1, 2, and 3, respectively. The duration of diabetic mellitus (DM), glycated hemoglobin (HbA1c), log hsCRP, and log PTX3 were significantly different between the three groups (P = 0.008, P < 0.001, P = 0.046, and P < 0.001, respectively). In subgroup analysis, plasma log PTX3 levels increased in correlation with the severity of DR (R = 0.372, P < 0.001). Multivariate logistic analysis showed that the correlation between DR development and duration of DM and log PTX3 values was significant (P = 0.014 and P = 0.025, respectively), whereas correlation with log hsCRP values was not significant in univariate analysis (P = 0.129). The receiver operating characteristic curves of DR development were plotted using log PTX3 and log hsCRP values, and the area under the curves was found to be 0.721 (P = 0.001) and 0.614 (P = 0.087), respectively.CONCLUSIONS. Plasma PTX3 is positively associated with DR development and progression, and may be a more accurate predictor of DR development than hsCRP.