Intestinal microbiota-derived membrane vesicles and their role in chronic kidney disease.

Intestinal microbiota-derived membrane vesicles and their role in chronic kidney disease.
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DOI：
10.1016/j.bbadis.2022.166478
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发表时间：
2022-07
期刊：
Biochimica et biophysica acta. Molecular basis of disease
影响因子：
--
通讯作者：
Qin Wu;B. C. Liu;X. Ruan;K. Ma
Qin Wu;B. C. Liu;X. Ruan;K. Ma
中科院分区：
其他
文献类型：
--
作者：
Qin Wu;B. C. Liu;X. Ruan;K. Ma

文献摘要

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肠道微生物源性膜囊泡（MV）在免疫调节和维持肠道微生态系统中起着重要作用。MV和慢性肾脏病（CKD）之间的关系尚未确定。本文综述了不同囊泡类型的结构和生物学功能，总结了MVs介导的可能致病机制，对慢性肾脏病的诊断和治疗具有重要的临床意义。
Intestinal microbiota-derived membrane vesicles (MVs) play essential roles in immunomodulation and maintenance of the intestinal micro-ecosystem. The relationship between MVs and chronic kidney disease (CKD) has remained undefined. This review provides a survey of the structure and biological function of different vesicle types and summarizes the possible pathogenic mechanisms mediated by MVs, which may be of great clinical significance in the diagnosis and treatment of chronic kidney disease.