Comparison of right and left ventricular responses to left ventricular assist device support in patients with severe heart failure - A primary role of mechanical unloading underlying reverse remodeling
Comparison of right and left ventricular responses to left ventricular assist device support in patients with severe heart failure - A primary role of mechanical unloading underlying reverse remodeling
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DOI：
10.1161/hc3101.093903
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发表时间：
2001-08-07
期刊：
影响因子：
37.8
通讯作者：
Burkhoff, D
中科院分区：
文献类型：
--
作者：
Barbone, A;Holmes, JW;Burkhoff, D
背景：左心室辅助装置（LVAD）可导致严重心力衰竭的心室、心肌和全身异常（反向重构）。血流动力学卸载和规范化生化环境对逆转重塑的相对贡献尚不清楚。方法和结果：我们测量了53例没有LVAD支持（医疗支持）的移植患者的心脏结构和功能特征，以及33例接受LVAD支持（8至360天）的患者的心脏结构和功能特征。与单纯药物支持相比，接受LVAD支持≥30天的患者中心静脉压升高（11 +/-6 vs 8 +/-5 mmHg， P=0.04），肺动脉舒张压降低（14 +/-9 vs 21 +/-9 mmHg， P= 0.01），心输出量升高（5.1 +/-1.6 vs 3.7 +/-1.0 L/min， P= 0.01）
Background-Left ventricular assist devices (LVAD) reverse ventricular, myocardial, and systemic abnormalities characteristic of severe heart failure (reverse remodeling). The relative contributions of hemodynamic unloading and normalized biochemical milieu to reverse remodeling are unknown.Methods and Results-Structural and functional characteristics were measured from 53 hearts of patients undergoing transplantation without LVAD support (medical support) and 33 hearts from patients receiving a median of 46 days of LVAD support (range, 8 to 360 days). Compared with medical support alone, patients receiving LVAD support for greater than or equal to 30 days had higher central venous pressures (11 +/-6 versus 8 +/-5 mmHg, P=0.04), lower pulmonary artery diastolic pressures (14 +/-9 versus 21 +/-9 mm Hg, P= 0.01), and higher cardiac outputs (5.1 +/-1.6 versus 3.7 +/-1.0 L/min, P